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Details on Person Stalled 55S mitochondrial ribosome is dissociated to yield 28S subunit and 39S subunit:mRNA:peptidyl-tRNA:tRNA

Class:Id	BlackBoxEvent:9937412
_displayName	Stalled 55S mitochondrial ribosome is dissociated to yield 28S subunit and 39S subunit:mRNA:peptidyl-tRNA:tRNA
_doRelease	TRUE
_timestamp	2025-05-17 00:58:12
authored	[InstanceEdit:9937408] May, Bruce, 2025-01-29
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:9937368] May, Bruce, 2025-01-31
edited	[InstanceEdit:9937408] May, Bruce, 2025-01-29
input	[Complex:9937399] 55S ribosome:mRNA:peptidyl-tRNA at P site:tRNA at E site [mitochondrial inner membrane] [Homo sapiens] [Complex:9937367] MALSU1:MIEF1:NDUFAB1 [mitochondrial inner membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9938470] Matthews, Lisa, 2025-02-16
isChimeric	FALSE
literatureReference	[LiteratureReference:9937389] Elongational stalling activates mitoribosome-associated quality control [LiteratureReference:9937363] Structures of the human mitochondrial ribosome in native states of assembly
modified	[InstanceEdit:9937665] May, Bruce, 2025-02-05 [InstanceEdit:9944101] May, Bruce, 2025-04-02 [InstanceEdit:9948135] May, Bruce, 2025-05-16 [InstanceEdit:9948136] May, Bruce, 2025-05-16 [InstanceEdit:9948194] May, Bruce, 2025-05-17
name	Stalled 55S mitochondrial ribosome is dissociated to yield 28S subunit and 39S subunit:mRNA:peptidyl-tRNA:tRNA
negativePrecedingEvent	[NegativePrecedingEvent:9948191] Futile Cycle: MTRFR:MTRES1:39S ribosomal subunit:mRNA:peptidyl-tRNA:MALSU1:MIEF1:NDUFAB1 dissociates
output	[Complex:5368239] 28S ribosomal subunit [mitochondrial inner membrane] [Homo sapiens] [Complex:9937397] 39S ribosomal subunit:mRNA:peptidyl-tRNA at P site:tRNA at E site:MALSU1:MIEF:NDUFAB1 [mitochondrial inner membrane] [Homo sapiens]
precedingEvent	[Reaction:5419279] Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) [Homo sapiens] [Reaction:5419261] 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-06-18
reviewed	[InstanceEdit:9948130] Keiler, Kenneth C, 2025-05-16 [InstanceEdit:9948133] Seerpatham, Divyasorubini, 2025-05-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9937449] R-HSA-9937412.1
summation	[Summation:9937655] Mitochondrial ribosomes that are stalled due to a defective ...
(hasEvent)	[Pathway:9937383] Mitochondrial ribosome-associated quality control [Homo sapiens]
(precedingEvent)	[Reaction:9937403] MTRFR:MTRES1 binds 39S ribosomal subunit:mRNA:peptidyl-tRNA:tRNA:MALSU1:MIEF1:NDUFAB1 [Homo sapiens]
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No pathways have been reviewed or authored by Stalled 55S mitochondrial ribosome is dissociated to yield 28S subunit and 39S subunit:mRNA:peptidyl-tRNA:tRNA (9937412)