Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person DHRSX (Polyprenol dehydrogenase) catalyzes the reduction of ...

Class:IdSummation:9937339
_displayNameDHRSX (Polyprenol dehydrogenase) catalyzes the reduction of ...
_timestamp2025-01-30 19:44:35
created[InstanceEdit:9937336] D'Eustachio, Peter, 2025-01-30
modified[InstanceEdit:9937346] D'Eustachio, Peter, 2025-01-30
textDHRSX (Polyprenol dehydrogenase) catalyzes the reduction of dolichal (DCHAL) to dolichol (DCHOL) coupled to the oxidation of NADPH + H+ to NADP+. Oxidoreductase reactions are reversible, and their direction is largely determined by the ratio of the reduced to the oxidized cofactor. In cells, the ratio of NAD+ to NADH is >100:1, while the ratio of NADP+ to NADPH is <1:10. DHRSX uses NAD and NADP with comparable efficiencies, so it is plausible that high cellular concentrations of NAD+ can drive DHRSX-catalyzed oxidation of polyprenol to polyprenal and high concentrations of NADPH can simultaneously drive DHRSX-catalyzed reductions of polyprenal and dolichal (Wilson et al. 2024).

The majority of DHRSX in cells expressing a FLAG-tagged construct is associated with lipid droplets and only a minor fraction is associated with the ER membrane (Wilson et al. 2024). Given the hydrophobic nature of the ER-associated substrate, however, the ER-localized form of the enzyme is annotated as the catalyst of this reaction.

(summation)[Reaction:9937340] DHRSX reduces dolichal to dolichol [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by DHRSX (Polyprenol dehydrogenase) catalyzes the reduction of ... (9937339)
Follow Reactome