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Details on Person DHRSX oxidizes polyprenol to polyprenal

Class:Id	Reaction:9937298
_displayName	DHRSX oxidizes polyprenol to polyprenal
_doRelease	TRUE
_timestamp	2025-02-26 19:05:08
authored	[InstanceEdit:9937271] D'Eustachio, Peter, 2025-01-29
catalystActivity	[CatalystActivity:9937286] polyprenol dehydrogenase (NAD+) activity of DHRSX [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9937281] polyprenol dehydrogenase activity of DHRSX [endoplasmic reticulum membrane] A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol [Compartment:5263266] cytoplasmic side of endoplasmic reticulum membrane
created	[InstanceEdit:9937296] D'Eustachio, Peter, 2025-01-30
crossReference	[DatabaseIdentifier:9937280] RHEA:80720
edited	[InstanceEdit:9938253] D'Eustachio, Peter, 2025-02-11
input	[SimpleEntity:4419981] pPNOL [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:29360] NAD+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:9937278] A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis
modified	[InstanceEdit:9937320] D'Eustachio, Peter, 2025-01-30 [InstanceEdit:9937325] D'Eustachio, Peter, 2025-01-30 [InstanceEdit:9939398] D'Eustachio, Peter, 2025-02-26 [InstanceEdit:9939400] D'Eustachio, Peter, 2025-02-26
name	DHRSX oxidizes polyprenol to polyprenal a di-trans,poly-cis-polyprenol + NAD(+) => a di-trans,poly-cis-polyprenal + NADH + H(+)
output	[SimpleEntity:70106] H+ [cytosol] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:9937308] pNAL [cytoplasmic side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:4419986] Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL [Homo sapiens] [Reaction:4419978] DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP [Homo sapiens]
releaseDate	2025-03-26
reviewed	[InstanceEdit:9939401] Hill, David P, 2025-02-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9937315] R-HSA-9937298.1
summation	[Summation:9937311] DHRSX (Polyprenol dehydrogenase) catalyzes the oxidation of ...
(hasEvent)	[Pathway:446199] Synthesis of dolichyl-phosphate [Homo sapiens]
(precedingEvent)	[Reaction:9937295] SRD5A3 reduces polyprenal to dolichal [Homo sapiens]
(replacementInstances)	[_Deleted:9937351] Deletion of instance: 4419979
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No pathways have been reviewed or authored by DHRSX oxidizes polyprenol to polyprenal (9937298)