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Details on Person SRD5A3 reduces polyprenal to dolichal

Class:IdReaction:9937295
_displayNameSRD5A3 reduces polyprenal to dolichal
_doReleaseTRUE
_timestamp2025-02-26 19:05:09
authored[InstanceEdit:9937271] D'Eustachio, Peter, 2025-01-29
catalystActivity[CatalystActivity:9937303] polyprenal reductase activity of SRD5A3 [endoplasmic reticulum membrane]
catalystActivityReference[CatalystActivityReference:9937313] polyprenal reductase activity of SRD5A3 [endoplasmic reticulum membrane] A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis
compartment[Compartment:5263266] cytoplasmic side of endoplasmic reticulum membrane
[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:9937296] D'Eustachio, Peter, 2025-01-30
crossReference[DatabaseIdentifier:9937285] RHEA:80729
edited[InstanceEdit:9938253] D'Eustachio, Peter, 2025-02-11
input[SimpleEntity:9937308] pNAL [cytoplasmic side of endoplasmic reticulum membrane]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:4420007] SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder
[LiteratureReference:4420042] Next generation sequencing in a family with autosomal recessive Kahrizi syndrome (OMIM 612713) reveals a homozygous frameshift mutation in SRD5A3
[LiteratureReference:4420017] SRD5A3-CDG: a patient with a novel mutation
[LiteratureReference:9937278] A pseudoautosomal glycosylation disorder prompts the revision of dolichol biosynthesis
modified[InstanceEdit:9937320] D'Eustachio, Peter, 2025-01-30
[InstanceEdit:9937325] D'Eustachio, Peter, 2025-01-30
[InstanceEdit:9939398] D'Eustachio, Peter, 2025-02-26
[InstanceEdit:9939400] D'Eustachio, Peter, 2025-02-26
nameSRD5A3 reduces polyprenal to dolichal
a di-trans,poly-cis-polyprenal + NADPH + H(+) => a di-trans,poly-cis-dolichal + NADP(+)
output[SimpleEntity:29366] NADP+ [cytosol]
[SimpleEntity:9937289] DCHAL [cytoplasmic side of endoplasmic reticulum membrane]
precedingEvent
releaseDate2025-03-26
reviewed[InstanceEdit:9939401] Hill, David P, 2025-02-26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9937316] R-HSA-9937295.1
summation[Summation:9937290] SRD5A3 (Polyprenal reductase) associated with the cytoplasmi...
(hasEvent)[Pathway:446199] Synthesis of dolichyl-phosphate [Homo sapiens]
(normalReaction)[FailedReaction:4755572] Defective SRD5A3 does not reduce pPNOL to DCHOL [Homo sapiens]
(precedingEvent)[Reaction:9937340] DHRSX reduces dolichal to dolichol [Homo sapiens]
(replacementInstances)[_Deleted:9937351] Deletion of instance: 4419979
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No pathways have been reviewed or authored by SRD5A3 reduces polyprenal to dolichal (9937295)
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