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Details on Person Coagulation factor XI circulates in plasma predominantly as ...

Class:IdSummation:9936462
_displayNameCoagulation factor XI circulates in plasma predominantly as ...
_timestamp2026-02-24 19:02:34
created[InstanceEdit:9936466] Shamovsky, Veronica, 2025-01-23
literatureReference[LiteratureReference:9936443] Platelet glycoprotein Ib: a zinc-dependent binding protein for the heavy chain of high-molecular-weight kininogen
[LiteratureReference:9936426] High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib
[LiteratureReference:9934228] Cell Receptor and Cofactor Interactions of the Contact Activation System and Factor XI
[LiteratureReference:9860375] Identification of a binding site for glycoprotein Ibalpha in the Apple 3 domain of factor XI
[LiteratureReference:9857961] Characterization of the H-kininogen-binding site on factor XI: a comparison of factor XI and plasma prekallikrein
[LiteratureReference:9909038] High molecular weight kininogen interactions with the homologs prekallikrein and factor XI: importance to surface-induced coagulation
[LiteratureReference:9909033] Structures of factor XI and prekallikrein bound to domain 6 of high-molecular weight kininogen reveal alternate domain 6 conformations and exosites
[LiteratureReference:158116] The relative priority of prekallikrein and factors XI/XIa assembly on cultured endothelial cells
modified[InstanceEdit:9983590] Shamovsky, Veronica, 2026-02-24
textCoagulation factor XI circulates in plasma predominantly as a non-covalent complex with high molecular weight kininogen (HK), encoded by the KNG1 gene (depicted here as KNG1(19-644)). HK anchors FXI to surfaces, facilitating its activation by factor FXIIa (Renné T et al., 2002; Li C et al., 2023; Mohammed BM et al., 2024). Both FXI and HK were shown to interact with the platelet glycoprotein GPIb:IX:V complex in a Zn²⁺-dependent manner (Joseph K et al., 1999; Chavakis T et al., 2003; Baglia FA et al., 2004; reviewed by Pathak M et al., 2018). Since the majority of FXI circulates bound to HK, it may also localize to endothelial cell membranes via HK interactions with cytokeratin 1 (CK1), urokinase plasminogen activator receptor (uPAR), and gC1qR (Mahdi F et al., 2003).
(summation)[Reaction:9936451] FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V [Homo sapiens]
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