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Details on Person FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V

Class:Id	Reaction:9936451
_displayName	FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V
_doRelease	TRUE
_timestamp	2026-01-27 16:13:08
authored	[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9936466] Shamovsky, Veronica, 2025-01-23
edited	[InstanceEdit:9980037] Shamovsky, Veronica, 2026-01-24
input	[Complex:9936459] factor XI:kininogen [extracellular region] [Homo sapiens] [Complex:114668] GPIb-IX-V [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9945130] D'Eustachio, Peter, 2025-04-10
isChimeric	FALSE
literatureReference	[LiteratureReference:9936443] Platelet glycoprotein Ib: a zinc-dependent binding protein for the heavy chain of high-molecular-weight kininogen [LiteratureReference:9936426] High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib [LiteratureReference:9860375] Identification of a binding site for glycoprotein Ibalpha in the Apple 3 domain of factor XI
modified	[InstanceEdit:9938571] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938657] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938801] Shamovsky, Veronica, 2025-02-19 [InstanceEdit:9938837] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9938874] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9946080] Shamovsky, Veronica, 2025-04-21 [InstanceEdit:9979500] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980335] Shamovsky, Veronica, 2026-01-27
name	FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V FXI:kininogen binds GPIb:IX:V
output	[Complex:9936436] FXI:KNG1:GPIb:IX:V [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9936440] FXI + kininogen -> FXI:kininogen [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
reviewed	[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9936475] R-HSA-9936451.1
summation	[Summation:9936462] Coagulation factor XI circulates in plasma predominantly as ...
(hasEvent)	[Pathway:9935598] FXIIa, PKa-dependent activation of coagulation pathway [Homo sapiens]
(precedingEvent)	[Reaction:9936430] factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) [Homo sapiens]
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No pathways have been reviewed or authored by FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V (9936451)