Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst)

Class:Id	Reaction:9936430
_displayName	factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst)
_doRelease	TRUE
_timestamp	2026-01-27 16:19:04
authored	[InstanceEdit:9929032] Shamovsky, Veronica, 2024-11-20
catalystActivity	[CatalystActivity:158386] serine-type endopeptidase activity of factor XIIa [extracellular region]
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9936466] Shamovsky, Veronica, 2025-01-23
edited	[InstanceEdit:9980037] Shamovsky, Veronica, 2026-01-24
input	[Complex:9936436] FXI:KNG1:GPIb:IX:V [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9945130] D'Eustachio, Peter, 2025-04-10
literatureReference	[LiteratureReference:9857836] A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo [LiteratureReference:158206] Human blood coagulation factor XI. Purification, properties, and mechanism of activation by activated factor XII. [LiteratureReference:158259] Activation of human factor XI (plasma thromboplastin antecedent) by factor XIIa (activated Hageman factor) [LiteratureReference:158171] Location of the disulfide bonds in human coagulation factor XI: the presence of tandem apple domains
modified	[InstanceEdit:9936480] Shamovsky, Veronica, 2025-01-23 [InstanceEdit:9938619] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938674] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938809] Shamovsky, Veronica, 2025-02-19 [InstanceEdit:9938851] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9946118] Shamovsky, Veronica, 2025-04-21 [InstanceEdit:9979555] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980356] Shamovsky, Veronica, 2026-01-27
name	factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst)
output	[Complex:9936479] FXIa:KNG1:GPIb:IX:V [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:158313] factor XII -> factor XIIa [Homo sapiens] [Reaction:158311] OBSOLETE_kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin_REPLACEMENT_9938539 [Homo sapiens] [Reaction:9655850] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (FXIIa catalyst) [Homo sapiens] [Reaction:9857945] prekallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1-> kallikrein:kininogen:C1QBP, C1QBP:KRT1, PLAUR:KRT1 (PRCP catalyst) [Homo sapiens] [Reaction:9909046] kallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor + factor XIIa (kallikrein catalyst) [Homo sapiens] [Reaction:9909048] prekallikrein:kininogen:cell surface receptor:factor XII -> kallikrein:kininogen:cell surface receptor:factor XII (FXII catalyst) [Homo sapiens] [Reaction:9857814] prekallikrein:kininogen:cell surface receptor:factor XII -> factor XIIa + prekallikrein:kininogen:cell surface receptor (FXII autocatalysis on the cell surface) [Homo sapiens] [Reaction:9855685] factor XII + prekallikrein:kininogen:cell surface receptor -> prekallikrein:kininogen:cell surface receptor:factor XII [Homo sapiens] [Reaction:9855735] factor XII:polyanionic activator -> factor XIIa + polyanionic activator (autocatalysis) [Homo sapiens] [Reaction:9855705] factor XII + polyanionic activator -> factor XII:polyanionic activator (in plasma) [Homo sapiens] [Reaction:9936451] FXI:kininogen + GPIb:IX:V -> FXI:kininogen:GPIb:IX:V [Homo sapiens] [Reaction:9936440] FXI + kininogen -> FXI:kininogen [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2026-03-25
reviewed	[InstanceEdit:9980333] Schmaier, Alvin H, 2026-01-27
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9936473] R-HSA-9936430.1
structureModified	[InstanceEdit:9936480] Shamovsky, Veronica, 2025-01-23
summation	[Summation:9936453] Coagulation factor XI (FXI), bound to the cell surface, is c...
(hasEvent)	[Pathway:9935598] FXIIa, PKa-dependent activation of coagulation pathway [Homo sapiens]
(precedingEvent)	[Reaction:9936467] factor IX -> factor IXa + factor IX activation peptide (kallikrein catalyst) [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by factor XI:kininogen:GPIb:IX:V complex -> factor XIa:kininogen:GPIb:IX:V complex (XIIa catalyst) (9936430)