Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person NSUN3 5-methylates cytosine-34 of mitochondrial tRNA(Met) (MT-TM)

Class:Id	Reaction:9936287
_displayName	NSUN3 5-methylates cytosine-34 of mitochondrial tRNA(Met) (MT-TM)
_timestamp	2025-02-05 14:27:54
authored	[InstanceEdit:9936256] May, Bruce, 2025-01-21
catalystActivity	[CatalystActivity:9936277] tRNA (cytidine-N5)-methyltransferase activity of NSUN3 [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9936282] May, Bruce, 2025-01-22
edited	[InstanceEdit:9936256] May, Bruce, 2025-01-21
input	[EntityWithAccessionedSequence:6792975] MT-TM [mitochondrial matrix] [Homo sapiens] [SimpleEntity:2162265] AdoMet [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:9936281] NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNA(Met) [LiteratureReference:9936272] Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3 [LiteratureReference:9936289] NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation
modified	[InstanceEdit:9937665] May, Bruce, 2025-02-05
name	NSUN3 5-methylates cytosine-34 of mitochondrial tRNA(Met) (MT-TM)
output	[EntityWithAccessionedSequence:9936241] 5mC34-MT-TM [mitochondrial matrix] [Homo sapiens] [SimpleEntity:2162252] AdoHcy [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:6785722] Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript [Homo sapiens] [BlackBoxEvent:9986204] POLRMT:TEFM:mitochondrial genome:H,L strand transcript:MTERF1 dissociates [Homo sapiens]
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9936314] R-HSA-9936287.1
summation	[Summation:9937659] NSUN3 methylates C5 of cytosine-34 (5mC34) of mitochondrial ...
(hasEvent)	[Pathway:6787450] tRNA modification in the mitochondrion [Homo sapiens] [Pathway:9936280] Mitochondrial tRNA modification-additional reactions [Homo sapiens]
(precedingEvent)	[Reaction:9936269] ALKBH1 oxidizes 5-methylcytosine to 5-formylcytosine at nucleotide 34 of mitochondrial tRNA(Met) (MT-TM) [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by NSUN3 5-methylates cytosine-34 of mitochondrial tRNA(Met) (MT-TM) (9936287)