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Details on Person RPUSD4 in the mitochondrial pseudouridylation module transforms uridine-1397 to pseudouridine-1397 in mitochondrial 16S rRNA

Class:Id	Reaction:9936243
_displayName	RPUSD4 in the mitochondrial pseudouridylation module transforms uridine-1397 to pseudouridine-1397 in mitochondrial 16S rRNA
_doRelease	TRUE
_timestamp	2025-12-06 10:30:53
authored	[InstanceEdit:9936256] May, Bruce, 2025-01-21
catalystActivity	[CatalystActivity:9936263] pseudouridine synthase activity of mitochondrial pseudouridylation module [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9936282] May, Bruce, 2025-01-22
edited	[InstanceEdit:9936256] May, Bruce, 2025-01-21
input	[EntityWithAccessionedSequence:6792998] 16S rRNA [mitochondrial matrix] [Homo sapiens]
internalReviewed	[InstanceEdit:9936566] May, Bruce, 2025-01-23
isChimeric	FALSE
literatureReference	[LiteratureReference:9837188] A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability [LiteratureReference:9936284] A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation [LiteratureReference:9936255] The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules
modified	[InstanceEdit:9940495] May, Bruce, 2025-03-06 [InstanceEdit:9944996] May, Bruce, 2025-04-08 [InstanceEdit:9976079] May, Bruce, 2025-12-06
name	RPUSD4 in the mitochondrial pseudouridylation module transforms uridine-1397 to pseudouridine-1397 in mitochondrial 16S rRNA
output	[EntityWithAccessionedSequence:9936242] 16S rRNA containing pseudouridinne-1397 [mitochondrial matrix] [Homo sapiens]
precedingEvent	[BlackBoxEvent:6785722] Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript [Homo sapiens] [BlackBoxEvent:9986204] POLRMT:TEFM:mitochondrial genome:H,L strand transcript:MTERF1 dissociates [Homo sapiens]
releaseDate	2025-06-18
reviewed	[InstanceEdit:9940494] Jourdain, Alexis A, 2025-03-04 [InstanceEdit:9944995] Mootha, Vamsi K, 2025-03-04 [InstanceEdit:9944993] Shoubridge, Eric A, 2025-04-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9936305] R-HSA-9936243.2
summation	[Summation:9936262] RPUSD4 is part of a larger complex, the mitochondrial pseudo...
(hasEvent)	[Pathway:6793080] rRNA modification in the mitochondrion [Homo sapiens] [Pathway:9936288] Mitochondrial rRNA modification-additional reactions [Homo sapiens]
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No pathways have been reviewed or authored by RPUSD4 in the mitochondrial pseudouridylation module transforms uridine-1397 to pseudouridine-1397 in mitochondrial 16S rRNA (9936243)