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Details on Person UniProt:Q9Y255 PRELID1
| Class:Id | ReferenceGeneProduct:99361 |
|---|---|
| _chainChangeLog | transit peptide:1-35 added on Sat February 7 2015;chain:36-219 added on Sat February 7 2015;transit peptide:1-35 removed on Fri May 8 2015;chain:36-219 removed on Fri May 8 2015;transit peptide:1- added on Fri May 8 2015;chain:-219 added on Fri May 8 2015 |
| _displayName | UniProt:Q9Y255 PRELID1 |
| _timestamp | 2024-11-03 20:11:37 |
| chain | transit peptide:1- chain:-219 |
| checksum | CCDBF54FA573509F |
| comment | FUNCTION Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phosphate(in) = a 1,2-diacyl-sn-glycero-3-phosphate(out)SUBUNIT Forms a complex with TRIAP1 in the mitochondrion intermembrane space. Interacts with OPA1 and AIFM1.SUBCELLULAR LOCATION Highly expressed in fetal liver; less expressed in fetal brain, lung, and kidney. At the adult stage, expression is drastically reduced in the liver but highly expressed in the spleen, brain, lung, lymph nodes and peripheral blood leukocytes.INDUCTION Up-regulated in response to activation in primary T helper cells. |
| description | recommendedName: PRELI domain-containing protein 1, mitochondrial alternativeName: 25 kDa protein of relevant evolutionary and lymphoid interest alternativeName: Px19-like protein |
| geneName | PRELID1 PRELI CGI-106 SBBI12 |
| identifier | Q9Y255 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Apoptosis Lipid transport Mitochondrion Proteomics identification Reference proteome Transit peptide Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PRELID1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990922] ENSEMBL:ENSG00000169230 PRELID1 [Homo sapiens] |
| secondaryIdentifier | PRLD1_HUMAN B2R5F7 D6RD25 Q549N2 Q9UI13 Q9UJS9 |
| sequenceLength | 219 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968955] UniProt:Q9Y255-1 PRELID1 [Homo sapiens] [ReferenceIsoform:8968956] UniProt:Q9Y255-2 PRELID1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6801215] PRELID1 [mitochondrial intermembrane space] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9Y255 PRELID1 (99361)
