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Details on Person The NEXT complex is bound to the RNA cap via ZC3H18. The MTR...
| Class:Id | Summation:9935622 |
|---|---|
| _displayName | The NEXT complex is bound to the RNA cap via ZC3H18. The MTR... |
| _timestamp | 2025-01-19 22:12:43 |
| created | [InstanceEdit:9935629] May, Bruce, 2025-01-17 |
| literatureReference | [LiteratureReference:9935633] The Nuclear RNA Exosome and Its Cofactors [LiteratureReference:9934096] Nuclear RNA Exosome and Pervasive Transcription: Dual Sculptors of Genome Function |
| modified | [InstanceEdit:9936009] May, Bruce, 2025-01-19 |
| text | The NEXT complex is bound to the RNA cap via ZC3H18. The MTREX (MTR4, SKIV2L2) subunit of the NEXT complex recruits the RNA exosome (Lubas et al. 2011, Andersen et al. 2013) to hydrolyze substrate RNA by 3'-5' exonuclease activities of the DIS3 and EXOSC10 subunits of the RNA exosome (Liu et al. 2006, Januszyk et al. 2011, Weick et al. 2018, reviewed in Schmid and Jensen 2019, Ogami and Suzuki 2021). The RNA exosome degrades pervasive intergenic transcripts after the transcripts have dissociated from chromatin (Agostini et al. 2021). |
| (summation) | [BlackBoxEvent:9934763] The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA [Homo sapiens] |
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No pathways have been reviewed or authored by The NEXT complex is bound to the RNA cap via ZC3H18. The MTR... (9935622)
