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Numerous transcription factors have been identified as di...
| Class:Id | Summation:9935602 |
|---|---|
| _displayName | Numerous transcription factors have been identified as di... |
| _timestamp | 2025-12-01 16:54:09 |
| created | [InstanceEdit:9935601] Orlic-Milacic, Marija, 2025-01-16 |
| modified | [InstanceEdit:9935611] Orlic-Milacic, Marija, 2025-01-17 [InstanceEdit:9935615] Orlic-Milacic, Marija, 2025-01-17 [InstanceEdit:9936186] Orlic-Milacic, Marija, 2025-01-21 [InstanceEdit:9936205] Orlic-Milacic, Marija, 2025-01-21 [InstanceEdit:9936209] Orlic-Milacic, Marija, 2025-01-21 [InstanceEdit:9975419] Orlic-Milacic, Marija, 2025-12-01 |
| text | Numerous transcription factors have been identified as direct positive regulators of CDH1 gene (also known as E-cadherin, epithelial cadherin, Cadherin-1, CADH1, or uvomorulin) transcription, including ARID1A (Yan et al. 2014; Baldi et al. 2022), FOXA2 (Zhang et al. 2015; Bow et al. 2020; Liu et al. 2021), FOXJ2 (Martin de Lara et al. 2008; Zhang et al. 2018), KLF4 (Yori et al. 2010; Bjerke et al. 2011; Koopmansch et al. 2013; Lee et al. 2014; Lin et al. 2018), KLF9 (Zhong et al. 2018; Bai et al. 2021), RB1 (Batsche et al. 1998; Decary et al. 2002; Arima et al. 2008), SP1 (Mauro et al. 2007; Jin and Datta 2014; Zhang et al. 2022), and TFAP2A (Faraldo et al. 1997; Batsche et al. 1998; Decary et al. 2002; Schwartz et al. 2007; Arima et al. 2008). Downregulation of the CDH1 gene expression is one of the hallmarks of epithelial-to-mesenchymal transition, seen normally during development and wound healing, but also pathologically, during cancer progression (reviewed in Serrano-Gomez et al. 2016). Expression of many negative regulators of the CDH1 gene is controlled by TGF-beta signaling (Peinado et al. 2003; Choi et al. 2007; Vincent et al. 2009; Brandl et al. 2010; Livitsanou et al. 2018), prostaglandin E(2) signaling (Dohadwala et al. 2006), WNT signaling (Huang et al. 2008; Khan et al. 2013), and NFκB signaling (Julien et al. 2007; Brandl et al. 2010; Hung et al. 2015). Well-established direct repressors of the CDH1 gene include SNAI1 (SNAIL) (Cano et al. 2000; Batlle et al. 2000; Peinado et la. 2004; Herranz et al. 2008; Hou et al. 2010; Dong et al. 2013; Lu et al. 2014; Villarejo et al. 2014; Maturi et al. 2018), SNAI2 (SLUG) (Hajra et al. 2002; Hayashida et al, 2006; Saito et al. 2004; Saito et al, 2006; Ferrari-Amorotti et al. 2013; Villarejo et al. 2014), TWIST1 (Vesuna et al. 2008, Yang et al. 2012), TWIST2 (Yang et al. 2016, Wang et al. 2021), WT1 (Brett et al. 2013; Wu et al. 2013; Han et al. 2020), ZBTB33 (Jones et al. 2012, Jones et al. 2014), ZEB1 (Kokura et al. 2010; Mazda et al. 2011; Aghdassi et al. 2012; Hou et al. 2016; Sun et al. 2015; Yao et al. 2017; ), ZEB2 (Ghoumid et al. 2013; He et al. 2017), and ZNF217 (Cowger et al. 2007, Nunez et al. 2011, Si et al. 2019). Several splicing isoforms of CDH1 mRNA/protein exist and inclusion of some exons of CDH1 was shown to be regulated by the SWI/SNF complex (Batsché et al. 2006). |
| (summation) | [Pathway:9764560] Regulation of CDH1 Gene Transcription [Homo sapiens] |
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Numerous transcription factors have been identified as di... (9935602)
