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Details on Person Ubiquitinated CDH1 translocates to lysosomes for degradation

Class:Id	BlackBoxEvent:9935552
_displayName	Ubiquitinated CDH1 translocates to lysosomes for degradation
_doRelease	TRUE
_timestamp	2025-12-01 19:38:01
authored	[InstanceEdit:9934754] Orlic-Milacic, Marija, 2025-01-10
compartment	[Compartment:171062] early endosome membrane [Compartment:17938] lysosomal membrane
created	[InstanceEdit:9935551] Orlic-Milacic, Marija, 2025-01-15
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
input	[Complex:9935413] CBLL1:PolyUb-p-2Y-CDH1 [early endosome membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimeric	FALSE
literatureReference	[LiteratureReference:9935106] Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent [LiteratureReference:9934839] An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin [LiteratureReference:9935502] Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway [LiteratureReference:9935530] Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress
modified	[InstanceEdit:9935566] Orlic-Milacic, Marija, 2025-01-15 [InstanceEdit:9935577] Orlic-Milacic, Marija, 2025-01-15 [InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17 [InstanceEdit:9935647] Orlic-Milacic, Marija, 2025-01-17 [InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20 [InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23 [InstanceEdit:9975426] Orlic-Milacic, Marija, 2025-12-01
name	Ubiquitinated CDH1 translocates to lysosomes for degradation
output	[Complex:9935550] CBLL1:PolyUb-p-2Y-CDH1 [lysosomal membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9934752] Ubiquitinated CDH1 is endocytosed [Homo sapiens] [Reaction:9934753] CBLL1 ubiquitinates CDH1 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-06-18
reviewed	[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9935561] R-HSA-9935552.2
summation	[Summation:9935565] ARF6, RAB5, and RAB7 were reported to be involved in traffic...
(hasEvent)	[Pathway:9766229] Degradation of CDH1 [Homo sapiens] [Pathway:9958810] SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9935547] Lysosomal degradation of ubiquitinated CDH1 [Homo sapiens]
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