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Details on Person Lysosomal degradation of ubiquitinated CDH1

Class:IdBlackBoxEvent:9935547
_displayNameLysosomal degradation of ubiquitinated CDH1
_doReleaseTRUE
_timestamp2026-01-27 16:10:54
authored[InstanceEdit:9935551] Orlic-Milacic, Marija, 2025-01-15
catalystActivity[CatalystActivity:9935541] peptidase activity of (CTSB,CTSL,CTSS) [lysosomal lumen]
compartment[Compartment:17938] lysosomal membrane
created[InstanceEdit:9935551] Orlic-Milacic, Marija, 2025-01-15
edited[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
input[Complex:9935550] CBLL1:PolyUb-p-2Y-CDH1 [lysosomal membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimericFALSE
literatureReference[LiteratureReference:9935567] Distinct roles for cysteine cathepsin genes in multistage tumorigenesis
[LiteratureReference:9935106] Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent
[LiteratureReference:9934839] An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin
[LiteratureReference:9935502] Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway
[LiteratureReference:9935530] Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress
[LiteratureReference:9935578] Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions
modified[InstanceEdit:9935575] Orlic-Milacic, Marija, 2025-01-15
[InstanceEdit:9935577] Orlic-Milacic, Marija, 2025-01-15
[InstanceEdit:9935583] Orlic-Milacic, Marija, 2025-01-16
[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
[InstanceEdit:9935647] Orlic-Milacic, Marija, 2025-01-17
[InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20
[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
[InstanceEdit:9975426] Orlic-Milacic, Marija, 2025-12-01
[InstanceEdit:9980324] Orlic-Milacic, Marija, 2026-01-27
nameLysosomal degradation of ubiquitinated CDH1
output[Complex:8876991] CBLL1 dimer:Zn2+ [cytosol] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2025-06-18
reviewed[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9935553] R-HSA-9935547.2
summation[Summation:9935573] CBLL1 (Hakai)-ubiquitinated CDH1 (E-cadherin) is preferentia...
(hasEvent)[Pathway:9766229] Degradation of CDH1 [Homo sapiens]
[Pathway:9958810] SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9954116] Futile Cycle: Lysosomal degradation of ubiquitinated CDH1
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No pathways have been reviewed or authored by Lysosomal degradation of ubiquitinated CDH1 (9935547)
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