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Details on Person XRN2 exonucleolytically cleaves 5' monophosphorylated RNAs (...

Class:IdSummation:9935285
_displayNameXRN2 exonucleolytically cleaves 5' monophosphorylated RNAs (...
_timestamp2025-01-18 20:21:33
created[InstanceEdit:9935313] May, Bruce, 2025-01-14
literatureReference[LiteratureReference:9935294] Rixosomal RNA degradation contributes to silencing of Polycomb target genes
[LiteratureReference:9935797] Nuclear RNA Regulation by XRN2 and XTBD Family Proteins
[LiteratureReference:9935778] The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination
[LiteratureReference:9935828] 5'-exonuclease-2 of Saccharomyces cerevisiae. Purification and features of ribonuclease activity with comparison to 5'-exonuclease-1
[LiteratureReference:9935817] mRNA decapping factors and the exonuclease Xrn2 function in widespread premature termination of RNA polymerase II transcription
[LiteratureReference:9935623] Intergenic RNA mainly derives from nascent transcripts of known genes
[LiteratureReference:9935845] Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites
modified[InstanceEdit:9935882] May, Bruce, 2025-01-18
textXRN2 exonucleolytically cleaves 5' monophosphorylated RNAs (inferred from the yeast homolog Rat1 in Stevens and Poole 1995, reviewed in Aygun and Miki 2021) such as decapped RNAs (Brannan et al. 2012) and the 3' RNA products of cleavage during transcription termination by autocatalytic self-cleavage (West et al. 2004) and by the cleavage and polyadenylation (CPA) complex (Kaneko et al. 2007) and by the rixosome (Zhou et al. 2022). XRN2 also degrades intergenic transcripts that remain bound to chromatin (Agostini et al 2021).
(summation)[BlackBoxEvent:9935299] XRN2 5'-3' exonucleolytically hydrolyzes uncapped RNA [Homo sapiens]
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