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Details on Person NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome

Class:Id	Reaction:9935282
_displayName	NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome
_doRelease	TRUE
_timestamp	2025-10-23 05:41:13
authored	[InstanceEdit:9935059] May, Bruce, 2025-01-12
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9935313] May, Bruce, 2025-01-14
edited	[InstanceEdit:9935059] May, Bruce, 2025-01-12
input	[Complex:9930060] NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] [Homo sapiens] [Complex:9933578] RNA exosome [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
literatureReference	[LiteratureReference:9934084] ARS2 instructs early transcription termination-coupled RNA decay by recruiting ZC3H4 to nascent transcripts [LiteratureReference:9934095] A restrictor complex of ZC3H4, WDR82, and ARS2 integrates with PNUTS to control unproductive transcription [LiteratureReference:9934516] The human cap-binding complex is functionally connected to the nuclear RNA exosome [LiteratureReference:6791506] C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing
modified	[InstanceEdit:9935642] May, Bruce, 2025-01-17 [InstanceEdit:9935882] May, Bruce, 2025-01-18 [InstanceEdit:9936006] May, Bruce, 2025-01-19 [InstanceEdit:9936835] May, Bruce, 2025-01-27 [InstanceEdit:9938522] May, Bruce, 2025-02-17 [InstanceEdit:9939324] May, Bruce, 2025-02-25 [InstanceEdit:9969612] May, Bruce, 2025-10-23
name	NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome
output	[Complex:9935306] RNA exosome:NEXT:ZC3H4:CBCA:m7GpppN-RNA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9930059] The NEXT complex binds ZC3H4:WDR82:CBCA:m7GpppN-RNA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9969603] Tong, Liang, 2025-10-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9935328] R-HSA-9935282.2
summation	[Summation:9935636] The EXOSC10 (RRP6, PM/Scl-100) subunit of the RNA exosome in...
(hasEvent)	[Pathway:9930044] Nuclear RNA decay [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9935290] The RNA exosome in RNA exosome:NEXT:ZC3H4:WDR82:CBCA:capped RNA hydrolyzes capped RNA [Homo sapiens]
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No pathways have been reviewed or authored by NEXT:ZC3H4:CBCA:m7GpppN-RNA binds the RNA exosome (9935282)