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Details on Person Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent

Class:IdLiteratureReference:9935106
_displayNameReduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent
_timestamp2025-01-13 14:33:45
author[Person:9935111] Smyth, David
[Person:9935107] Leung, Gabriella
[Person:9935110] Fernando, Maria
[Person:9935109] McKay, Derek M
created[InstanceEdit:9935108] Orlic-Milacic, Marija, 2025-01-13
journalPLoS One
pagese38441
pubMedIdentifier22715382
titleReduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent
volume7
year2012
(literatureReference)[Pathway:9766229] Degradation of CDH1 [Homo sapiens]
[Reaction:9934751] CDH1 is phosphorylated on tyrosine residues [Homo sapiens]
[BlackBoxEvent:9934752] Ubiquitinated CDH1 is endocytosed [Homo sapiens]
[Reaction:9934753] CBLL1 ubiquitinates CDH1 [Homo sapiens]
[Reaction:9934755] CBLL1 binds p-Y-CDH1 [Homo sapiens]
[BlackBoxEvent:9935547] Lysosomal degradation of ubiquitinated CDH1 [Homo sapiens]
[BlackBoxEvent:9935552] Ubiquitinated CDH1 translocates to lysosomes for degradation [Homo sapiens]
[Summation:9934827]

In the canine MDCK cell line, CDH1 (E-cadherin) and CTNNB...
[Summation:9935073] Ectopic overexpression of a recombinant mouse CBLL1 (Hakai),...
[Summation:9935076] A recombinant mouse CBLL1 (Hakai), an E3 ubiquitin ligase, w...

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