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Details on Person Proteolysis of K48polyUb,p-S-CRY1,2

Class:Id	BlackBoxEvent:9934884
_displayName	Proteolysis of K48polyUb,p-S-CRY1,2
_doRelease	TRUE
_timestamp	2025-02-18 21:09:11
authored	[InstanceEdit:9934882] May, Bruce, 2025-01-11
catalystActivity	[CatalystActivity:174087] endopeptidase activity of 26S proteasome [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9934885] May, Bruce, 2025-01-12
edited	[InstanceEdit:9934882] May, Bruce, 2025-01-11
inferredFrom	[BlackBoxEvent:9934892] Proteolysis of K48polyUb,p-S-Cry1,2 [Mus musculus]
input	[DefinedSet:517938] K48polyUb-K,p-S-CRY1,2 [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
literatureReference	[LiteratureReference:9932876] FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes
modified	[InstanceEdit:9935063] May, Bruce, 2025-01-12 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938453] May, Bruce, 2025-02-14 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Proteolysis of K48polyUb,p-S-CRY1,2
output	[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9932512] FBXL3:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2 [Homo sapiens] [BlackBoxEvent:9909565] p-S-CRY:p-S-PER:CSNK1D,E complex translocates from the cytosol to the nucleus [Homo sapiens] [BlackBoxEvent:9923005] p-S-CRY:p-S-PER:CSNK1D,E:p-S90,Ac-538-BMAL1:p-4S,2T-CLOCK dissociates from target gene [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9934895] R-HSA-9934884.1
summation	[Summation:9934891] The proteasome degrades K48-polyubiquitinylated CRY1 and CRY...
(hasEvent)	[Pathway:9932298] Degradation of CRY and PER proteins [Homo sapiens]
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No pathways have been reviewed or authored by Proteolysis of K48polyUb,p-S-CRY1,2 (9934884)