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Details on Person An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin

Class:IdLiteratureReference:9934839
_displayNameAn acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin
_timestamp2025-01-11 05:03:53
author[Person:2453892] Chen, Ying
[Person:9934831] Chen, Chia-Huei
[Person:9934822] Tung, Po-Yuan
[Person:9934821] Huang, Shih-Horng
[Person:9934830] Wang, Seu-Mei
created[InstanceEdit:9934824] Orlic-Milacic, Marija, 2025-01-11
journalJ Cell Biochem
pages851-9
pubMedIdentifier19711372
titleAn acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin
volume108
year2009
(literatureReference)[Pathway:9766229] Degradation of CDH1 [Homo sapiens]
[Reaction:9934751] CDH1 is phosphorylated on tyrosine residues [Homo sapiens]
[BlackBoxEvent:9934752] Ubiquitinated CDH1 is endocytosed [Homo sapiens]
[Reaction:9934753] CBLL1 ubiquitinates CDH1 [Homo sapiens]
[Reaction:9934755] CBLL1 binds p-Y-CDH1 [Homo sapiens]
[BlackBoxEvent:9935547] Lysosomal degradation of ubiquitinated CDH1 [Homo sapiens]
[BlackBoxEvent:9935552] Ubiquitinated CDH1 translocates to lysosomes for degradation [Homo sapiens]
[Reaction:9958889] SRC phosphorylates CDH1 [Homo sapiens]
[Summation:9934827]

In the canine MDCK cell line, CDH1 (E-cadherin) and CTNNB...
[Summation:9935073] Ectopic overexpression of a recombinant mouse CBLL1 (Hakai),...

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