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Details on Person RORA,C positively regulate expression and NR1D1 negatively regulates expression of NR1D1 (REV-ERBA)

Class:IdBlackBoxEvent:9934780
_displayNameRORA,C positively regulate expression and NR1D1 negatively regulates expression of NR1D1 (REV-ERBA)
_doReleaseTRUE
_timestamp2025-02-18 21:11:10
authored[InstanceEdit:9934779] May, Bruce, 2025-01-10
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:9934776] May, Bruce, 2025-01-10
edited[InstanceEdit:9934779] May, Bruce, 2025-01-10
inferredFrom
input[EntityWithAccessionedSequence:5641202] NR1D1 gene [nucleoplasm] [Homo sapiens]
internalReviewed[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimericFALSE
literatureReference[LiteratureReference:9929996] Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone
[LiteratureReference:9930029] Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
[LiteratureReference:1480013] A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity
modified[InstanceEdit:9935064] May, Bruce, 2025-01-12
[InstanceEdit:9936865] May, Bruce, 2025-01-27
[InstanceEdit:9938453] May, Bruce, 2025-02-14
[InstanceEdit:9938697] May, Bruce, 2025-02-18
nameRORA,C positively regulate expression and NR1D1 negatively regulates expression of NR1D1 (REV-ERBA)
output[EntityWithAccessionedSequence:375499] NR1D1 [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
regulatedBy[PositiveGeneExpressionRegulation:9931514] Positive gene expression regulation by 'RORA,C:Coactivator:NR1D1 gene [nucleoplasm]'
[NegativeGeneExpressionRegulation:9933507] Negative gene expression regulation by 'NR1D1:heme:Corepressors:NR1D1 gene [nucleoplasm]'
regulationReference[RegulationReference:9933501] Negative gene expression regulation by 'NR1D1:heme:Corepressors:NR1D1 gene [nucleoplasm]' A functional Rev-erb alpha responsive element located in the human Rev-erb alpha promoter mediates a repressing activity
releaseDate2025-03-26
reviewed[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14
[InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9934783] R-HSA-9934780.1
summation[Summation:9934781] RORA and RORC bind ROR response elements (RREs, ROREs) in th...
(hasEvent)[Pathway:9933387] RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression [Homo sapiens]
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No pathways have been reviewed or authored by RORA,C positively regulate expression and NR1D1 negatively regulates expression of NR1D1 (REV-ERBA) (9934780)
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