Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA

Class:Id	BlackBoxEvent:9934763
_displayName	The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA
_doRelease	TRUE
_timestamp	2025-10-23 05:44:31
authored	[InstanceEdit:9934545] May, Bruce, 2025-01-08
catalystActivity	[CatalystActivity:9934761] 3'-5'-RNA exonuclease activity of RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9934762] May, Bruce, 2025-01-10
edited	[InstanceEdit:9934545] May, Bruce, 2025-01-08
input	[Complex:9934534] RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
literatureReference	[LiteratureReference:9935623] Intergenic RNA mainly derives from nascent transcripts of known genes [LiteratureReference:9934516] The human cap-binding complex is functionally connected to the nuclear RNA exosome [LiteratureReference:8985575] Interaction profiling identifies the human nuclear exosome targeting complex [LiteratureReference:9935627] Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex [LiteratureReference:9935634] Activities of human RRP6 and structure of the human RRP6 catalytic domain [LiteratureReference:433047] Reconstitution, activities, and structure of the eukaryotic RNA exosome
modified	[InstanceEdit:9935347] May, Bruce, 2025-01-14 [InstanceEdit:9935642] May, Bruce, 2025-01-17 [InstanceEdit:9936006] May, Bruce, 2025-01-19 [InstanceEdit:9936835] May, Bruce, 2025-01-27 [InstanceEdit:9938522] May, Bruce, 2025-02-17 [InstanceEdit:9939324] May, Bruce, 2025-02-25 [InstanceEdit:9969612] May, Bruce, 2025-10-23
name	The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA
output	[EntityWithAccessionedSequence:9930040] ZC3H18 [nucleoplasm] [Homo sapiens] [Complex:9930043] CBCA complex [nucleoplasm] [Homo sapiens] [Complex:9933578] RNA exosome [nucleoplasm] [Homo sapiens] [Complex:9935998] NEXT homodimer [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9934522] NEXT:ZC3H18:CBCA:m7GpppN-RNA binds the RNA exosome [Homo sapiens] [Reaction:9930056] The NEXT complex and ZC3H18 bind CBCA:m7GpppN-RNA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9969603] Tong, Liang, 2025-10-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9934764] R-HSA-9934763.2
structureModified	[InstanceEdit:9936006] May, Bruce, 2025-01-19
summation	[Summation:9935622] The NEXT complex is bound to the RNA cap via ZC3H18. The MTR...
(hasEvent)	[Pathway:9930044] Nuclear RNA decay [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by The RNA exosome in RNA exosome:NEXT:ZC3H18:CBCA:m7GpppN-RNA hydrolyzes RNA (9934763)