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Details on Person CBLL1 binds p-Y-CDH1

Class:IdReaction:9934755
_displayNameCBLL1 binds p-Y-CDH1
_doReleaseTRUE
_timestamp2025-12-01 19:37:31
authored[InstanceEdit:9934754] Orlic-Milacic, Marija, 2025-01-10
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:9934754] Orlic-Milacic, Marija, 2025-01-10
edited[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
input[Complex:8876991] CBLL1 dimer:Zn2+ [cytosol] [Homo sapiens]
[Complex:8876991] CBLL1 dimer:Zn2+ [cytosol] [Homo sapiens]
[DefinedSet:9934825] Man,Man9GlucNAc2,p-3S,2Y-CDH1:p-Y-CTNND1 [plasma membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimericFALSE
literatureReference[LiteratureReference:9935106] Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent
[LiteratureReference:9934839] An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin
[LiteratureReference:9935502] Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway
[LiteratureReference:9935530] Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress
modified[InstanceEdit:9935115] Orlic-Milacic, Marija, 2025-01-13
[InstanceEdit:9935139] Orlic-Milacic, Marija, 2025-01-13
[InstanceEdit:9935236] Orlic-Milacic, Marija, 2025-01-14
[InstanceEdit:9935506] Orlic-Milacic, Marija, 2025-01-15
[InstanceEdit:9935540] Orlic-Milacic, Marija, 2025-01-15
[InstanceEdit:9935577] Orlic-Milacic, Marija, 2025-01-15
[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
[InstanceEdit:9935647] Orlic-Milacic, Marija, 2025-01-17
[InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20
[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
[InstanceEdit:9954118] Orlic-Milacic, Marija, 2025-06-05
[InstanceEdit:9975426] Orlic-Milacic, Marija, 2025-12-01
nameCBLL1 binds p-Y-CDH1
negativePrecedingEvent[NegativePrecedingEvent:9954116] Futile Cycle: Lysosomal degradation of ubiquitinated CDH1
output[Complex:9935231] CBLL1:p-2Y-CDH1 [plasma membrane] [Homo sapiens]
[Complex:9935231] CBLL1:p-2Y-CDH1 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:418996] CTNND1 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:418996] CTNND1 [plasma membrane] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2025-06-18
reviewed[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9934759] R-HSA-9934755.3
structureModified[InstanceEdit:9935236] Orlic-Milacic, Marija, 2025-01-14
[InstanceEdit:9935540] Orlic-Milacic, Marija, 2025-01-15
summation[Summation:9935114]

In the canine cell line MDCK, endogenous CBLL1 (Hakai), a...

(hasEvent)[Pathway:9766229] Degradation of CDH1 [Homo sapiens]
[Pathway:9958810] SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) [Homo sapiens]
(precedingEvent)[Reaction:9934753] CBLL1 ubiquitinates CDH1 [Homo sapiens]
[NegativePrecedingEvent:9954068] Futile Cycle: CBLL1 binds p-Y-CDH1
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No pathways have been reviewed or authored by CBLL1 binds p-Y-CDH1 (9934755)
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