Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person CBLL1 ubiquitinates CDH1

Class:Id	Reaction:9934753
_displayName	CBLL1 ubiquitinates CDH1
_doRelease	TRUE
_timestamp	2025-12-01 19:37:35
authored	[InstanceEdit:9934754] Orlic-Milacic, Marija, 2025-01-10
catalystActivity	[CatalystActivity:9935239] ubiquitin-protein transferase activity of CBLL1:p-2Y-CDH1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9934754] Orlic-Milacic, Marija, 2025-01-10
edited	[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
input	[DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens] [Complex:9935231] CBLL1:p-2Y-CDH1 [plasma membrane] [Homo sapiens]
internalReviewed	[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimeric	FALSE
literatureReference	[LiteratureReference:9935106] Reduced surface expression of epithelial E-cadherin evoked by interferon-gamma is Fyn kinase-dependent [LiteratureReference:9934839] An acidic extracellular pH disrupts adherens junctions in HepG2 cells by Src kinases-dependent modification of E-cadherin [LiteratureReference:9935502] Cdc42 regulates E-cadherin ubiquitination and degradation through an epidermal growth factor receptor to Src-mediated pathway [LiteratureReference:9935530] Basolateral CD147 induces hepatocyte polarity loss by E-cadherin ubiquitination and degradation in hepatocellular carcinoma progress [LiteratureReference:9935578] Minus end-directed motor KIFC3 suppresses E-cadherin degradation by recruiting USP47 to adherens junctions
modified	[InstanceEdit:9935077] Orlic-Milacic, Marija, 2025-01-13 [InstanceEdit:9935115] Orlic-Milacic, Marija, 2025-01-13 [InstanceEdit:9935139] Orlic-Milacic, Marija, 2025-01-13 [InstanceEdit:9935255] Orlic-Milacic, Marija, 2025-01-14 [InstanceEdit:9935506] Orlic-Milacic, Marija, 2025-01-15 [InstanceEdit:9935563] Orlic-Milacic, Marija, 2025-01-15 [InstanceEdit:9935577] Orlic-Milacic, Marija, 2025-01-15 [InstanceEdit:9935583] Orlic-Milacic, Marija, 2025-01-16 [InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17 [InstanceEdit:9935647] Orlic-Milacic, Marija, 2025-01-17 [InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20 [InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23 [InstanceEdit:9954118] Orlic-Milacic, Marija, 2025-06-05 [InstanceEdit:9975426] Orlic-Milacic, Marija, 2025-12-01
name	CBLL1 ubiquitinates CDH1
negativePrecedingEvent	[NegativePrecedingEvent:9954069] Futile Cycle: Proteasome-dependent degradation of ubiquitinated CDH1
output	[Complex:9935237] CBLL1:PolyUb-p-2Y-CDH1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:9934755] CBLL1 binds p-Y-CDH1 [Homo sapiens] [Reaction:9934751] CDH1 is phosphorylated on tyrosine residues [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-06-18
reviewed	[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9934758] R-HSA-9934753.3
structureModified	[InstanceEdit:9935255] Orlic-Milacic, Marija, 2025-01-14 [InstanceEdit:9935563] Orlic-Milacic, Marija, 2025-01-15
summation	[Summation:9935076] A recombinant mouse CBLL1 (Hakai), an E3 ubiquitin ligase, w...
(hasEvent)	[Pathway:9766229] Degradation of CDH1 [Homo sapiens] [Pathway:9958810] SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9934752] Ubiquitinated CDH1 is endocytosed [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by CBLL1 ubiquitinates CDH1 (9934753)