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Details on Person CTNNA1 (α-catenin) is responsible for the recruitment of F-a...

Class:IdSummation:9934484
_displayNameCTNNA1 (α-catenin) is responsible for the recruitment of F-a...
_timestamp2025-12-01 16:54:43
created[InstanceEdit:9934483] Orlic-Milacic, Marija, 2025-01-08
literatureReference[LiteratureReference:9934437] Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions
[LiteratureReference:9934434] Dynamics and functions of E-cadherin complexes in epithelial cell and tissue morphogenesis
[LiteratureReference:9934488] alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells
[LiteratureReference:9934304] Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction
modified[InstanceEdit:9936228] Orlic-Milacic, Marija, 2025-01-22
[InstanceEdit:9975419] Orlic-Milacic, Marija, 2025-12-01
textCTNNA1 (α-catenin) is responsible for the recruitment of F-actin polymers to the CDH1 complex (Watabe-Uchida et al. 1998: human colon carcinoma cell line; Wu et al. 2015: human epidermoid carcinoma cell line; Morales-Camilo et al. 2024: canine MDCK cell line; reviewed in Zhang et al. 2023). CTNNA1 can dimerize when clustered, which increases its binding affinity for F-actin (reviewed in Zhang et al. 2023).
(summation)[Reaction:9934486] CDH1-associated CTNNA1 binds F-actin [Homo sapiens]
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