Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person CDH1 (E-cadherin) forms cis-homodimers/cis-homo-oligomers en...

Class:IdSummation:9934430
_displayNameCDH1 (E-cadherin) forms cis-homodimers/cis-homo-oligomers en...
_timestamp2025-12-01 16:54:18
created[InstanceEdit:9934431] Orlic-Milacic, Marija, 2025-01-08
literatureReference[LiteratureReference:9762154] Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation
[LiteratureReference:9934437] Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions
[LiteratureReference:9934434] Dynamics and functions of E-cadherin complexes in epithelial cell and tissue morphogenesis
modified[InstanceEdit:9934433] Orlic-Milacic, Marija, 2025-01-08
[InstanceEdit:9934443] Orlic-Milacic, Marija, 2025-01-08
[InstanceEdit:9936226] Orlic-Milacic, Marija, 2025-01-22
[InstanceEdit:9936227] Orlic-Milacic, Marija, 2025-01-22
[InstanceEdit:9975419] Orlic-Milacic, Marija, 2025-12-01
textCDH1 (E-cadherin) forms cis-homodimers/cis-homo-oligomers engaging laterally, through extracellular domains, with CDH1 molecule(s) expressed in the same cell in a calcium-independent and catenin-independent manner (Chitaev and Troyanovsky 1998). Using super-resolution microscopy techniques it was found that loosely organized cis-clusters of approximately five CDH1 molecules form, that are delimited by the cortical F-actin meshwork, and that serve as the precursors of trans-ligated adhesive clusters that make up the adherens junction (Wu et al. 2015; reviewed in Zhang et al. 2023).
(summation)[Reaction:9934411] CDH1 forms cis-clusters [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by CDH1 (E-cadherin) forms cis-homodimers/cis-homo-oligomers en... (9934430)
Follow Reactome