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Details on Person CDH1 (E-cadherin) forms a homotypic trans-complex with CDH1 ...
| Class:Id | Summation:9934421 |
|---|---|
| _displayName | CDH1 (E-cadherin) forms a homotypic trans-complex with CDH1 ... |
| _timestamp | 2025-12-01 16:54:17 |
| created | [InstanceEdit:9934419] Orlic-Milacic, Marija, 2025-01-08 |
| literatureReference | [LiteratureReference:9762154] Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation [LiteratureReference:201971] Structural basis of calcium-induced E-cadherin rigidification and dimerization [LiteratureReference:9934425] Calcium binding and homoassociation of E-cadherin domains [LiteratureReference:9934437] Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions [LiteratureReference:9934434] Dynamics and functions of E-cadherin complexes in epithelial cell and tissue morphogenesis |
| modified | [InstanceEdit:9934429] Orlic-Milacic, Marija, 2025-01-08 [InstanceEdit:9934433] Orlic-Milacic, Marija, 2025-01-08 [InstanceEdit:9934443] Orlic-Milacic, Marija, 2025-01-08 [InstanceEdit:9934512] Orlic-Milacic, Marija, 2025-01-08 [InstanceEdit:9936230] Orlic-Milacic, Marija, 2025-01-22 [InstanceEdit:9975419] Orlic-Milacic, Marija, 2025-12-01 |
| text | CDH1 (E-cadherin) forms a homotypic trans-complex with CDH1 molecules presented on the plasma membrane of a neighbouring cell, where two CDH1 molecules interact through their extracellular domains in a calcium (Ca2+)-dependent, and catenin-dependent manner (Chitaev and Troyanovski 1998). Based on a structural study using the extracellular domain of the mouse CDH1, it was determined that twelve Ca2+ ions per CDH1 molecule were needed for homotypic dimerization (Nagar et al. 1996). Another study with the mouse CDH1 reported that nine Ca2+ ions per CDH1 molecule were sufficient for homotypic dimerization (Koch et al. 1997). Using super-resolution microscopy techniques it was found that loosely organized cis-clusters of approximately five CDH1 molecules serve as the precursors of trans-ligated adhesive clusters, consisting of homotypic trans-dimers, that make up the adherens junction (Wu et al. 2015; reviewed in Zhang et al. 2023). CDH1 clusters in both interacting cells are surrounded by the cytosolic F-actin meshwork, but the F-actin meshwork is not necessary for the establishment of homotypic trans-interactions (Wu et al. 2015). |
| (summation) | [Reaction:9934410] CDH1 forms homotypic trans-dimers [Homo sapiens] |
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No pathways have been reviewed or authored by CDH1 (E-cadherin) forms a homotypic trans-complex with CDH1 ... (9934421)
