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Details on Person CDH1 forms homotypic trans-dimers

Class:IdReaction:9934410
_displayNameCDH1 forms homotypic trans-dimers
_doReleaseTRUE
_timestamp2025-12-01 16:54:31
authored[InstanceEdit:9934412] Orlic-Milacic, Marija, 2025-01-08
compartment[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created[InstanceEdit:9934412] Orlic-Milacic, Marija, 2025-01-08
edited[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
entityOnOtherCell[Complex:9934440] trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane] [Homo sapiens]
input[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[SimpleEntity:74112] Ca2+ [extracellular region]
[Complex:9934440] trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane] [Homo sapiens]
[Complex:9934501] Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] [Homo sapiens]
internalReviewed[InstanceEdit:9936137] Rothfels, Karen, 2025-01-20
isChimericFALSE
literatureReference[LiteratureReference:9762154] Adhesive but not lateral E-cadherin complexes require calcium and catenins for their formation
[LiteratureReference:9934437] Actin-delimited adhesion-independent clustering of E-cadherin forms the nanoscale building blocks of adherens junctions
modified[InstanceEdit:9934424] Orlic-Milacic, Marija, 2025-01-08
[InstanceEdit:9934443] Orlic-Milacic, Marija, 2025-01-08
[InstanceEdit:9934494] Orlic-Milacic, Marija, 2025-01-08
[InstanceEdit:9934505] Orlic-Milacic, Marija, 2025-01-08
[InstanceEdit:9935645] Orlic-Milacic, Marija, 2025-01-17
[InstanceEdit:9935647] Orlic-Milacic, Marija, 2025-01-17
[InstanceEdit:9936139] Orlic-Milacic, Marija, 2025-01-20
[InstanceEdit:9949646] Orlic-Milacic, Marija, 2025-05-23
[InstanceEdit:9954118] Orlic-Milacic, Marija, 2025-06-05
[InstanceEdit:9975419] Orlic-Milacic, Marija, 2025-12-01
nameCDH1 forms homotypic trans-dimers
output[Complex:9934435] Homotypic CDH1 trans-dimer cluster [plasma membrane] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2025-06-18
reviewed[InstanceEdit:9975417] Raptis, Leda, 2025-11-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9934414] R-HSA-9934410.3
structureModified[InstanceEdit:9934424] Orlic-Milacic, Marija, 2025-01-08
[InstanceEdit:9934443] Orlic-Milacic, Marija, 2025-01-08
[InstanceEdit:9934505] Orlic-Milacic, Marija, 2025-01-08
summation[Summation:9934421] CDH1 (E-cadherin) forms a homotypic trans-complex with CDH1 ...
(hasEvent)[Pathway:9764561] Regulation of CDH1 Function [Homo sapiens]
[Pathway:9958825] Activation of STAT3 by cadherin engagement [Homo sapiens]
(precedingEvent)[BlackBoxEvent:9959445] DISPUTED BY AUTHORS: Cell-to-cell contact through homophilic cadherin interactions promotes transient RAC1,(CDC42) activation [Homo sapiens]
(updatedInstance)[_UpdateTracker:9984624] Update Tracker - [Reaction:9934410] CDH1 forms homotypic trans-dimers - v96:[modifyText]
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No pathways have been reviewed or authored by CDH1 forms homotypic trans-dimers (9934410)