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Details on Person ANK3 (Ankyrin-G), a scaffold protein that links membrane pro...

Class:IdSummation:9934332
_displayNameANK3 (Ankyrin-G), a scaffold protein that links membrane pro...
_timestamp2025-01-09 05:41:06
created[InstanceEdit:9934321] Orlic-Milacic, Marija, 2025-01-07
literatureReference[LiteratureReference:9934328] Dynamic interactions between E-cadherin and Ankyrin-G mediate epithelial cell polarity maintenance
[LiteratureReference:9934564] Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos
[LiteratureReference:9934573] E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin
modified[InstanceEdit:9934571] Orlic-Milacic, Marija, 2025-01-09
[InstanceEdit:9934577] Orlic-Milacic, Marija, 2025-01-09
textANK3 (Ankyrin-G), a scaffold protein that links membrane proteins to the spectrin-based cytoskeleton, binds to the complex of CDH1 (E-cadherin) and CTNNB1 (beta-catenin) through the interaction between the cytosolic tail of CDH1 and ankyrin repeats of ANK3 (Kizhatil et al. 2007: endogenous proteins in human bronchoepithelial cells and early mouse embryos and recombinant human CDH1, rat ANK3 and CTNNB1 of unspecified origin; Kong et al. 2023: study performed in canine MDCK cell line). It is assumed that ANK3 can similarly bind to the complex of CDH1 and JUP (plakoglobin). A recombinant human CDH1 deficient in ANK3 binding exhibits defective accumulation at the lateral plasma membrane when expressed in MDCK cells (Jenkins et al. 2013; Kong et al. 2023). ANK3 and beta-2-spectrin were shown to be required for accumulation of CDH1 at the lateral membrane in both human bronchial epithelial (HBE) cells, human HEK293 cells, and early mouse embryos (Kizhatil et al. 2007). Recombinant human CDH1 deficient for ANK3 binding is retained in Golgi when expressed in HBE cells (Kizhatil et al. 2007). ANK3 likely couples CDH1 to spectrin, which then facilitates transport of CDH1 to the plasma membrane via microtubule-dependent post-Golgi carriers (Kizhatil et al. 2007).
(summation)[Reaction:9934330] CDH1:CTNNB1,JUP complex binds to ANK3 [Homo sapiens]
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