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Details on Person Vinculin (VCL) was first shown to be recruited to the CDH1 c...
| Class:Id | Summation:9934307 |
|---|---|
| _displayName | Vinculin (VCL) was first shown to be recruited to the CDH1 c... |
| _timestamp | 2025-12-01 16:54:58 |
| created | [InstanceEdit:9934308] Orlic-Milacic, Marija, 2025-01-07 |
| literatureReference | [LiteratureReference:9934299] The zonula adherens matura redefines the apical junction of intestinal epithelia [LiteratureReference:9934304] Alternative molecular mechanisms for force transmission at adherens junctions via β-catenin-vinculin interaction [LiteratureReference:9934488] alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells [LiteratureReference:9934434] Dynamics and functions of E-cadherin complexes in epithelial cell and tissue morphogenesis [LiteratureReference:9934499] Nanoscale architecture of cadherin-based cell adhesions |
| modified | [InstanceEdit:9934500] Orlic-Milacic, Marija, 2025-01-08 [InstanceEdit:9934512] Orlic-Milacic, Marija, 2025-01-08 [InstanceEdit:9934544] Orlic-Milacic, Marija, 2025-01-08 [InstanceEdit:9936229] Orlic-Milacic, Marija, 2025-01-22 [InstanceEdit:9975419] Orlic-Milacic, Marija, 2025-12-01 |
| text | Vinculin (VCL) was first shown to be recruited to the CDH1 complex through its interaction with CTNNA1 (α-catenin) in a human colon carcinoma cell line (Watabe-Uchida et al. 1998). Using high resolution microscopy experiments in the canine MDCK cell line, it was shown that vinculin (VCL) is recruited to the CDH1 (E-cadherin) complex through simultaneous interaction with CTNNA1 and CTNNB1 (Bertocchi et al. 2017; Morales-Camilo et al. 2024; reviewed in Zhang et al. 2023). Mechanical force-induced conformational change of CTNNA1 is thought to expose VCL binding sites (Bertocchi et al. 2017). The initial interaction with CTNNA1 is needed to induce a conformational change of VCL into a more open conformation, which then enables its interaction with CTNNB1 (Morales-Camilo et al. 2024). VCL may stabilize the interaction between CTNNA1 and F-actin (Mangeol et al. 2024). In human intestinal cells, vinculin was shown to be simultaneously associated with the CDH1 complex and with the nectin-afadin complex at the adherens junctions, possibly through ponsin, which is known to interact with both VCL and afadin (Mangeol et al. 2024). |
| (summation) | [Reaction:9934294] CDH1-associated CTNNA1 binds VCL [Homo sapiens] |
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No pathways have been reviewed or authored by Vinculin (VCL) was first shown to be recruited to the CDH1 c... (9934307)
