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Details on Person The CBCA complex (CBP80:CBP20:ARS2, also called NCBP1:NCBP2:...
| Class:Id | Summation:9934103 |
|---|---|
| _displayName | The CBCA complex (CBP80:CBP20:ARS2, also called NCBP1:NCBP2:... |
| _timestamp | 2025-10-23 05:42:51 |
| created | [InstanceEdit:9934086] May, Bruce, 2025-01-06 |
| literatureReference | [LiteratureReference:9934078] Nuclear mRNA decay: regulatory networks that control gene expression |
| modified | [InstanceEdit:9934545] May, Bruce, 2025-01-08 [InstanceEdit:9935347] May, Bruce, 2025-01-14 [InstanceEdit:9935642] May, Bruce, 2025-01-17 [InstanceEdit:9936006] May, Bruce, 2025-01-19 [InstanceEdit:9936009] May, Bruce, 2025-01-19 [InstanceEdit:9936617] May, Bruce, 2025-01-24 [InstanceEdit:9936618] May, Bruce, 2025-01-24 [InstanceEdit:9969612] May, Bruce, 2025-10-23 |
| text | The CBCA complex (CBP80:CBP20:ARS2, also called NCBP1:NCBP2:SRRT) is bound to the m7GpppN cap of an RNA. ZC3H18 interacts with the SRRT (ARS2) subunit of the CBCA complex (Winczura et al. 2018, Polák et al. 2023) and the NEXT complex (RBM7:ZCCHC8:MTREX) (Lubas et al. 2011, Winczura et al. 2018) to form the CBCN complex (Andersen et al. 2013). The NEXT complex binds lower amounts of RNA exosome components than CBCA components suggesting that some portion of the CBCN complex is not bound to the RNA exosome (Andersen et al. 2013). The NEXT complex binds ZC3H18 as a homodimer and all subunits of the NEXT complex participate in interaction with RNA (Puno and Lima 2022, Gerlach et al. 2022). Substrate RNAs of NEXT are generally not polyadenylated, do not have polyadenylation sequences (Wu et al. 2020), and include promoter upstream transcripts (PROMPTS) and enhancer RNAs (eRNAs) (Lubas et al. 2015). ZC3H18 is believed to initiate degradation of RNAs that are produced from paused transcripts released from transcription complexes by the endonucleolytic activity of the Integrator complex (reviewed in Rambout and Maquat 2024). ZC3H18, which interacts with the NEXT complex, and ZC3H1, which interacts with the PAXT connection, compete for binding to the same site on SRRT (ARS2) (Polák et al. 2023). The PAXT connection may thus compete with the NEXT complex for substrate RNAs and may act as a fail-safe system for RNAs that escape targeting by NEXT (Wu et al. 2020) |
| (summation) | [Reaction:9930056] The NEXT complex and ZC3H18 bind CBCA:m7GpppN-RNA [Homo sapiens] |
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No pathways have been reviewed or authored by The CBCA complex (CBP80:CBP20:ARS2, also called NCBP1:NCBP2:... (9934103)
