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Details on Person During RNA transcription, ZFC3H1 binds the first exon and fi...
| Class:Id | Summation:9933583 |
|---|---|
| _displayName | During RNA transcription, ZFC3H1 binds the first exon and fi... |
| _timestamp | 2025-01-19 22:12:28 |
| created | [InstanceEdit:9933586] May, Bruce, 2025-01-02 |
| modified | [InstanceEdit:9934109] May, Bruce, 2025-01-06 [InstanceEdit:9935347] May, Bruce, 2025-01-14 [InstanceEdit:9935642] May, Bruce, 2025-01-17 [InstanceEdit:9935882] May, Bruce, 2025-01-18 [InstanceEdit:9936009] May, Bruce, 2025-01-19 |
| text | During RNA transcription, ZFC3H1 binds the first exon and first intron of nascent RNAs (Fan et al. 2024). On short RNAs with few exons (Fan et al. 2024) ZFC3H1 then binds MTREX (MTR4, SKIV2L2), forming the PAXT connection: ZFC3H1:MTREX (Meola et al. 2016, Fan et al. 2024). ZFC3H1 of the PAXT connection binds ARS2 (SRRT) of the cap binding complex CBCA (Meola et al. 2016, Polak et al. 2023) and the binding is mostly RNA-sensitive (Meola et al. 2016). ZFC3H1 also interacts with PABPN1 bound to the polyadenylate tail of the RNA, thus PAXT is targeted to capped, polyadenylated RNAs (Meola et al. 2016). ZFC3H1 of PAXT and ZC3H18 associated with the NEXT complex compete for binding to the ARS2 (SRRT) subunit of the CBCA complex (Polak et al. 2023), determining whether the RNA will be degraded by the PAXT-dependent pathway or the NEXT-dependent pathway. ZC3H3 directly interacts with the PAXT connection independently of RNA. (Silla et al. 2020). Both RBM27 and its paralog RBM26 are present in the larger PAXT:PARN2:ZC3H3 complex and participate in PAXT-dependent RNA decay (Silla et al. 2020, Contreras et al. 2023). The polyadenylate polymerase PAPOLG (PAPgamma) interacts with ZFC3H1 of the PAXT connection and appears to participate in 3' polyadenylation of promoter upstream transcripts (PROMPTs) (Contreras et al. 2023). As judged by coimmunoprecipitation, the 6-methyladenosine readers YTHDC1 and YTHDC2 also associate with ZFC3H1 (Contreras et al. 2023). The overall subunit composition of the larger PAXT complex resembles the MTREC complex of yeast (Contreras et al. 2023). |
| (summation) | [Reaction:9933559] The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 [Homo sapiens] |
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