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Details on Person MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome

Class:Id	Reaction:9933575
_displayName	MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome
_doRelease	TRUE
_timestamp	2025-10-23 05:40:19
authored	[InstanceEdit:9930071] May, Bruce, 2024-12-01
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9933586] May, Bruce, 2025-01-02
edited	[InstanceEdit:9930071] May, Bruce, 2024-12-01
input	[Complex:9933554] PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] [Homo sapiens] [Complex:9933578] RNA exosome [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
literatureReference	[LiteratureReference:9933568] Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting [LiteratureReference:9933564] Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts [LiteratureReference:9933557] The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay [LiteratureReference:6791506] C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing
modified	[InstanceEdit:9935059] May, Bruce, 2025-01-12 [InstanceEdit:9935347] May, Bruce, 2025-01-14 [InstanceEdit:9935882] May, Bruce, 2025-01-18 [InstanceEdit:9936835] May, Bruce, 2025-01-27 [InstanceEdit:9938522] May, Bruce, 2025-02-17 [InstanceEdit:9939324] May, Bruce, 2025-02-25 [InstanceEdit:9969612] May, Bruce, 2025-10-23
name	MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome
output	[Complex:9933591] PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9933559] The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9969603] Tong, Liang, 2025-10-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9933602] R-HSA-9933575.2
summation	[Summation:9935790] The EXOSC10 (RRP6, PM/Scl-100) subunit of the RNA exosome as...
(hasEvent)	[Pathway:9930044] Nuclear RNA decay [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9933585] RNA exosome in PAXT:PAPOLG:TENT4A,B:ZC3H3:CBCA:polyadenylated m7GpppN-RNA:PABPN1 hydrolyzes RNA [Homo sapiens]
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No pathways have been reviewed or authored by MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome (9933575)