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Details on Person PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm]

Class:Id	Complex:9933554
_displayName	PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm]
_timestamp	2025-01-18 20:21:01
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9933586] May, Bruce, 2025-01-02
hasComponent	[Complex:9933582] CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] [Homo sapiens] [GenomeEncodedEntity:9930038] 3'-polyadenylated m7GpppN-RNA [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:72008] PABPN1 [nucleoplasm] [Homo sapiens] [Complex:9930043] CBCA complex [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:51469] NCBP1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:51463] NCBP2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6814858] SRRT [nucleoplasm] [Homo sapiens] [Complex:9930036] PAXT connection [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6791189] SKIV2L2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9930046] ZFC3H1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9933572] ZC3H3 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9934098] PAPOLG [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9935784] RBM26 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9935838] RBM27 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9935812] YTHDC1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9935827] YTHDC2 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9933568] Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting [LiteratureReference:9933564] Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts [LiteratureReference:9933557] The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay [LiteratureReference:9934077] PAPγ associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs
modified	[InstanceEdit:9934109] May, Bruce, 2025-01-06 [InstanceEdit:9935059] May, Bruce, 2025-01-12 [InstanceEdit:9935347] May, Bruce, 2025-01-14 [InstanceEdit:9935882] May, Bruce, 2025-01-18
name	PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:capped, polyadenylated RNA:PABPN1
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9933598] R-HSA-9933554.1
(hasComponent)	[Complex:9933591] PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PAPBN1:RNA exosome [nucleoplasm] [Homo sapiens]
(input)	[Reaction:9933575] MTREX (MTR4, SKIV2L2) in PAXT:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 binds the RNA exosome [Homo sapiens]
(output)	[Reaction:9933559] The PAXT connection (ZFC3H1:MTREX, ZFC3H1:MTR4), RBM26, RBM27, PAPOLG, YTHDC1, and YTHDC2 bind CBCA:polyadenylated m7GpppN-RNA:PABPN1 [Homo sapiens]
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No pathways have been reviewed or authored by PAXT:PAPOLG:RBM26:RBM27:ZC3H3:YTHDC1:YTHDC2:CBCA:polyadenylated m7GpppN-RNA:PABPN1 [nucleoplasm] (9933554)