Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person Mammalian SWI/SNF complexes are ATP-dependent chromatin remo...
| Class:Id | Summation:9933243 |
|---|---|
| _displayName | Mammalian SWI/SNF complexes are ATP-dependent chromatin remo... |
| _timestamp | 2025-02-21 14:54:30 |
| created | [InstanceEdit:9933244] Rothfels, Karen, 2024-12-27 |
| modified | [InstanceEdit:9933245] Rothfels, Karen, 2024-12-27 [InstanceEdit:9933288] Rothfels, Karen, 2024-12-27 [InstanceEdit:9933410] Rothfels, Karen, 2024-12-30 [InstanceEdit:9933944] Rothfels, Karen, 2025-01-05 [InstanceEdit:9934169] Rothfels, Karen, 2025-01-06 [InstanceEdit:9934292] Rothfels, Karen, 2025-01-07 [InstanceEdit:9938989] Rothfels, Karen, 2025-02-21 |
| text | Mammalian SWI/SNF complexes are ATP-dependent chromatin remodellers with a central catalytic ATPase consisting of either SMARCA2 (also known as BRM) or SMARCA4 (BRG1), bromodomain-containing proteins that bind acetylated histones (Hassan et al, 2002; Hyun et al, 2024; reviewed in Eustermann et al, 2024). In addition to SMARCA2/4, SWI/SNF complexes also contain varied organizations of 10-14 other proteins, many of which were initially identified as BAFs (BRM/BRG1 associated factors). This module describes the assembly of three well characterized SWI/SNF complexes, the canonical BAF (cBAF), equivalent to the SWI/SNF complex from S. cerevisiae, the polybromo-containing BAF (pBAF) (equivalent to the RSC complex from S. cerevisiae) and the more recently elucidated non-canonical BAF (ncBAF) (He et al, 2020; Mashtalir et al, 2018; Mashtalir et al, 2020; Wang et al, 2022; Yuan et al, 2022; Alpsoy and Dykhuizen, 2018; Michel et al, 2018). All three complexes share catalytic subunits (SMARCA2 or SMARCA4) as well as combinations of 5 other common proteins/protein families (ACTB, ACTL6A/B, BCL7A/B/C, SMARCD1/2/3 and SMARCC1/2) and are additionally distinguished by complex-specific subunits (He et al, 2020; Mashtalir et al, 2018; Wang et al, 2022; Yuan et al, 2022; Alpsoy and Dykhuizen, 2018; Eustermann et al, 2024). In addition to these three complexes, other SWI/SNF complexes have been identified that play tissue-, cell- or developmental-specific roles (see for instance, Lessard et al, 2007; Ho,Ronan et al, 2009; Ho, Jothi et al, 2009; Zhang et al, 2014) but fundamentally all are involved in chromatin assembly or remodelling through alterations of histone-DNA contacts (reviewed in Eustermann et al, 2024; Cenik and Shilatifard, 2021). Mutations in components of SWI/SNF complexes are frequent in cancers and other diseases (Kadoch et al, 2013; reviewed in Mittal and Roberts, 2020; Kadoch and Crabtree, 2015; Cenik and Shilatifard, 2021; Wang and Tang, 2023). Cryo-EM, cross-linking and gradient sedimentation have revealed the modular organization of mammalian SWI/SNF complexes (He et al, 2020; Mashtalir et al, 2018; Mashtalir et al, 2020). The ATPase module contains most of the catalytic portion of the SMARCA2/4 protein and wraps around the nucleosomal DNA. Closely associated with the catalytic module is a domain consisting of ACTB and ACTL6A/B, as well as SMARCB1 and BCL7 paralogs. A core or base module consisting of the SMARCC dimer and SMARCE1, supplemented by many of the complex-specific subunits, makes contact with the bottom side of the nucleosome (He et al, 2020). |
| (summation) | [Pathway:9932451] SWI/SNF chromatin remodelers [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by Mammalian SWI/SNF complexes are ATP-dependent chromatin remo... (9933243)
