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Details on Person The SCF ubiquitin E3 ligase complex Btrc:Cul1:Skp1:Rbx1 bind...

Class:IdSummation:9933189
_displayNameThe SCF ubiquitin E3 ligase complex Btrc:Cul1:Skp1:Rbx1 bind...
_timestamp2025-01-22 18:28:58
created[InstanceEdit:9933186] May, Bruce, 2024-12-26
literatureReference[LiteratureReference:517948] The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2
[LiteratureReference:517934] Beta-TrCP1-mediated degradation of PERIOD2 is essential for circadian dynamics
[LiteratureReference:400336] Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation
modified[InstanceEdit:9934287] May, Bruce, 2025-01-07
[InstanceEdit:9935064] May, Bruce, 2025-01-12
[InstanceEdit:9936399] May, Bruce, 2025-01-22
textThe SCF ubiquitin E3 ligase complex Btrc:Cul1:Skp1:Rbx1 binds phosphorylated mouse Per1 (Shirogane et al.2005) and, by inference other Per proteins, and catalyzes the polymerization of ubiquitin from ubiquitin:E2 complexes onto an unidentified lysine residue of Per1 (Shirogane et al. 2005) and Per2 (inferred from Btrc-dependent decay of Per2 in mouse cells in Eide et al. 2005, Reischl et al. 2007, Ohsaki et al. 2008).
(summation)[BlackBoxEvent:9932505] Btrc:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Per1,2,3 [Mus musculus]
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