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Details on Person The SCF ubiquitin E3 ligase complex BTRC,FBXW11:CUL1:SKP1:RB...
| Class:Id | Summation:9933185 |
|---|---|
| _displayName | The SCF ubiquitin E3 ligase complex BTRC,FBXW11:CUL1:SKP1:RB... |
| _timestamp | 2025-01-22 18:28:56 |
| created | [InstanceEdit:9933186] May, Bruce, 2024-12-26 |
| literatureReference | [LiteratureReference:517948] The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2 [LiteratureReference:517934] Beta-TrCP1-mediated degradation of PERIOD2 is essential for circadian dynamics [LiteratureReference:400336] Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation |
| modified | [InstanceEdit:9935063] May, Bruce, 2025-01-12 [InstanceEdit:9935064] May, Bruce, 2025-01-12 [InstanceEdit:9936399] May, Bruce, 2025-01-22 |
| text | The SCF ubiquitin E3 ligase complex BTRC,FBXW11:CUL1:SKP1:RBX1, which contains either BTRC (beta-TrCP) or FBXW11 (beta-TrCP2), binds phosphorylated PER1 (Shirogane et al. 2005) and PER2 (inferred from mouse homologs in Eide et al. 2005, Reischl et al. 2007, Ohsaki et al. 2008) and catalyzes the polymerization of ubiquitin from ubiquitin:E2 complexes onto an unidentified lysine residue of PER1 (Shirogane et al. 2005) and PER2 (inferred from BTRC-dependent decay of PER2 in mouse cells in Eide et al. 2005, Reischl et al. 2007, Ohsaki et al. 2008). Based on the observed decay of PER proteins, the ubiquitin polymers contain K48 linkages between the ubiquitin subunits and target the ubiquitinylated PER1 and PER2 for proteolysis by the 26S proteasome. |
| (summation) | [BlackBoxEvent:9932510] BTRC:CUL1:SKP1:RBX1 (SCF-beta-TrCP1) ubiquitinylates phosphorylated PER1,2,3 [Homo sapiens] |
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No pathways have been reviewed or authored by The SCF ubiquitin E3 ligase complex BTRC,FBXW11:CUL1:SKP1:RB... (9933185)
