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Details on Person PHF10 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD7

Class:Id	Reaction:9932843
_displayName	PHF10 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD7
_doRelease	TRUE
_timestamp	2025-02-27 14:03:36
authored	[InstanceEdit:9934146] Rothfels, Karen, 2025-01-06
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9932845] Rothfels, Karen, 2024-12-20
edited	[InstanceEdit:9934146] Rothfels, Karen, 2025-01-06
input	[Complex:9932833] SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD7 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9932814] PHF10 [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9933882] Orlic-Milacic, Marija, 2025-01-05
isChimeric	FALSE
literatureReference	[LiteratureReference:9932803] Structure of human chromatin-remodelling PBAF complex bound to a nucleosome [LiteratureReference:9932752] Structure of nucleosome-bound human PBAF complex [LiteratureReference:9932366] A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms [LiteratureReference:9932772] A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation [LiteratureReference:9727476] Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes [LiteratureReference:9932782] PHF10 subunit of PBAF complex mediates transcriptional activation by MYC
modified	[InstanceEdit:9934144] Rothfels, Karen, 2025-01-06 [InstanceEdit:9934147] Rothfels, Karen, 2025-01-06 [InstanceEdit:9934292] Rothfels, Karen, 2025-01-07 [InstanceEdit:9938993] Rothfels, Karen, 2025-02-21 [InstanceEdit:9939454] Rothfels, Karen, 2025-02-27
name	PHF10 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD7
negativePrecedingEvent	[NegativePrecedingEvent:9934140] Futile Cycle: Formation of neural BAF (nBAF)
output	[Complex:9932844] SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD7:PHF10 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9932832] BRD7 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2 [Homo sapiens] [Reaction:9932440] ARID2 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938992] Dykhuizen, Emily C, 2025-02-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9932846] R-HSA-9932843.1
summation	[Summation:9932820] PHF10 is a bromodomain-containing protein that is specifical...
(hasEvent)	[Pathway:9933939] Formation of the polybromo-BAF (pBAF) complex [Homo sapiens]
(precedingEvent)	[Reaction:9933237] PBRM1-containing ATPase complex binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD&:PHF10 [Homo sapiens]
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No pathways have been reviewed or authored by PHF10 binds SMARCC dimer:SMARCDs:SMARCE1:SMARCB1:ARID2:BRD7 (9932843)