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Details on Person Fbxl3:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2

Class:Id	BlackBoxEvent:9932501
_displayName	Fbxl3:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2
_doRelease	TRUE
_timestamp	2025-02-28 00:48:24
authored	[InstanceEdit:9932569] May, Bruce, 2024-12-20
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9932525] May, Bruce, 2024-12-20
edited	[InstanceEdit:9932569] May, Bruce, 2024-12-20
input	[Complex:9932490] Fbxl3:Cul1:Skp1:Rbx1:p-S-Cry1,2 [nucleoplasm] [Mus musculus] [Complex:9932507] Ub:Ube2d1 [nucleoplasm] [Mus musculus] [Complex:9932507] Ub:Ube2d1 [nucleoplasm] [Mus musculus] [Complex:9932507] Ub:Ube2d1 [nucleoplasm] [Mus musculus]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
literatureReference	[LiteratureReference:400236] SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins [LiteratureReference:9932516] Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm [LiteratureReference:9932876] FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes
modified	[InstanceEdit:9932907] May, Bruce, 2024-12-20 [InstanceEdit:9933147] May, Bruce, 2024-12-24 [InstanceEdit:9933330] May, Bruce, 2024-12-28 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938453] May, Bruce, 2025-02-14 [InstanceEdit:9938517] May, Bruce, 2025-02-17 [InstanceEdit:9938697] May, Bruce, 2025-02-18 [InstanceEdit:9939539] May, Bruce, 2025-02-28
name	Fbxl3:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2
output	[DefinedSet:517929] K48polyUb,p-S-Cry1,2 [nucleoplasm] [Mus musculus] [Complex:9932511] Fbxl3:Cul1:Skp1:Rbx1 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9932492] Ube2d1 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9932492] Ube2d1 [nucleoplasm] [Mus musculus] [EntityWithAccessionedSequence:9932492] Ube2d1 [nucleoplasm] [Mus musculus]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9932561] R-MMU-9932501.1
structureModified	[InstanceEdit:9932907] May, Bruce, 2024-12-20
summation	[Summation:9933314] The Fbxl3:Cul1:Skp1:Rbx1 SCF E3 ligase complex polyubiqutiny...
(inferredFrom)	[BlackBoxEvent:9932512] FBXL3:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2 [Homo sapiens]
(replacementInstances)	[_Deleted:9939520] Deletion of instance: 517959
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No pathways have been reviewed or authored by Fbxl3:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2 (9932501)