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Details on Person
CDH1 (also known as E-cadherin, epithelial cadherin, Cadh...
| Class:Id | Summation:9932163 |
|---|---|
| _displayName | CDH1 (also known as E-cadherin, epithelial cadherin, Cadh... |
| _timestamp | 2025-01-21 22:31:28 |
| created | [InstanceEdit:9932153] Orlic-Milacic, Marija, 2024-12-17 |
| literatureReference | [LiteratureReference:9932154] E-cadherin signal sequence disruption: a novel mechanism underlying hereditary cancer [LiteratureReference:9932161] Characterization of recombinant E-cadherin (uvomorulin) expressed in insect cells [LiteratureReference:9833168] Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage |
| modified | [InstanceEdit:9932172] Orlic-Milacic, Marija, 2024-12-17 [InstanceEdit:9936189] Orlic-Milacic, Marija, 2025-01-21 [InstanceEdit:9936208] Orlic-Milacic, Marija, 2025-01-21 |
| text | CDH1 (also known as E-cadherin, epithelial cadherin, Cadherin-1, CADH1, or uvomorulin) contains a signal peptide at the very N-terminus (Herrenknecht and Kemler 1993; Figueiredo et al. 2018) that is likely cleaved by the signal peptidase complex in the endoplasmic reticulum membrane (Liaci et al. 2021), although no direct evidence is available. CDH1 gene mutations that disrupt the signal sequence have been reported in the hereditary diffuse gastric cancer and found to interfere with CDH1 translation and translocation to the endoplasmic reticulum (Figueiredo et al. 2018). |
| (summation) | [BlackBoxEvent:9932162] Removal of CDH1 signal peptide [Homo sapiens] |
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CDH1 (also known as E-cadherin, epithelial cadherin, Cadh... (9932163)
