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Details on Person Cdk5 phosphorylates CLOCK on serine 451 and serine-461

Class:IdReaction:9932082
_displayNameCdk5 phosphorylates CLOCK on serine 451 and serine-461
_doReleaseTRUE
_timestamp2025-02-18 21:01:34
authored[InstanceEdit:9932068] May, Bruce, 2024-12-15
catalystActivity[CatalystActivity:9920653] protein serine/threonine kinase activity of Cdk5 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:9932069] May, Bruce, 2024-12-17
edited[InstanceEdit:9932068] May, Bruce, 2024-12-15
input[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[EntityWithAccessionedSequence:400392] CLOCK [cytosol] [Homo sapiens]
internalReviewed[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimericTRUE
literatureReference[LiteratureReference:9912394] Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation
modified[InstanceEdit:9936865] May, Bruce, 2025-01-27
[InstanceEdit:9938391] May, Bruce, 2025-02-14
[InstanceEdit:9938517] May, Bruce, 2025-02-17
[InstanceEdit:9938697] May, Bruce, 2025-02-18
nameCdk5 phosphorylates CLOCK on serine 451 and serine-461
output[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[EntityWithAccessionedSequence:9912397] p-T451,T461-CLOCK [cytosol] [Homo sapiens]
previousReviewStatus[ReviewStatus:9821383] three stars
releaseDate2025-03-26
reviewed[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14
[InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
[Species:48892] Mus musculus
stableIdentifier[StableIdentifier:9932106] R-NUL-9932082.1
summation[Summation:9928750] Cyclin-dependent kinase 5 (CDK5) phosphorylates CLOCK on ser...
(inferredFrom)[Reaction:9912396] CDK5 phosphorylates CLOCK on serine-451 and serine-461 [Homo sapiens]
(replacementInstances)[_Deleted:9939502] Deletion of instance: 508656
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