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Details on Person RORA,C and coactivators bind the CLOCK gene

Class:Id	Reaction:9932081
_displayName	RORA,C and coactivators bind the CLOCK gene
_doRelease	TRUE
_timestamp	2025-02-18 21:10:46
authored	[InstanceEdit:9932068] May, Bruce, 2024-12-15
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9932069] May, Bruce, 2024-12-17
edited	[InstanceEdit:9932068] May, Bruce, 2024-12-15
inferredFrom	[Reaction:9932093] Rora,c and coactivators bind the Clock gene [Mus musculus]
input	[EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5640211] CLOCK gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4086031] NRIP1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:442481] PPARGC1A [nucleoplasm] [Homo sapiens] [DefinedSet:9931515] RORA,RORC [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
literatureReference	[LiteratureReference:1480024] Transcriptional regulation of human Rev-erbalpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha
modified	[InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938391] May, Bruce, 2025-02-14 [InstanceEdit:9938517] May, Bruce, 2025-02-17 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	RORA,C and coactivators bind the CLOCK gene
output	[Complex:9932073] RORA,C:Coactivators:CLOCK gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9922984] Phosphorylated BMAL1:CLOCK positively regulates expression of RORA [Homo sapiens] [Reaction:9923006] p-S90-BMAL1:p-T451,T461-CLOCK binds the RORA gene [Homo sapiens] [BlackBoxEvent:9925861] Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of RORC [Homo sapiens] [Reaction:9925862] p-S90-BMAL1:p-T451,T461-CLOCK and coactivators bind the RORC gene [Homo sapiens] [BlackBoxEvent:1368140] Expression of PPARGC1A (PGC-1alpha) [Homo sapiens] [Reaction:111912] CaMK4 phosphorylates CREB1 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9932102] R-HSA-9932081.1
summation	[Summation:9932088] Either RORA or RORC bind a single ROR response element (RRE....
(hasEvent)	[Pathway:9931509] Expression of BMAL (ARNTL), CLOCK, and NPAS2 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9932070] RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK [Homo sapiens]
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