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Details on Person Rora,c and coactivators positively regulate expression of Clock

Class:Id	BlackBoxEvent:9932080
_displayName	Rora,c and coactivators positively regulate expression of Clock
_doRelease	TRUE
_timestamp	2025-02-18 21:12:06
authored	[InstanceEdit:9932068] May, Bruce, 2024-12-15
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9932069] May, Bruce, 2024-12-17
edited	[InstanceEdit:9932068] May, Bruce, 2024-12-15
input	[EntityWithAccessionedSequence:5667083] Clock gene [nucleoplasm] [Mus musculus]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
literatureReference	[LiteratureReference:5669309] System-level identification of transcriptional circuits underlying mammalian circadian clocks [LiteratureReference:9926652] Chronobiological analysis of circadian patterns in transcription of seven key clock genes in six peripheral tissues in mice [LiteratureReference:9911573] RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo [LiteratureReference:1368179] Direct regulation of CLOCK expression by REV-ERB
modified	[InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938391] May, Bruce, 2025-02-14 [InstanceEdit:9938517] May, Bruce, 2025-02-17 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	Rora,c and coactivators positively regulate expression of Clock
output	[EntityWithAccessionedSequence:508720] Clock [cytosol] [Mus musculus]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeGeneExpressionRegulation:5667070] Negative gene expression regulation by 'Nr1d1:heme:Corepressors:Clock gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9932077] Positive gene expression regulation by 'Rora,c:Coactivators:Clock gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9931507] Positive gene expression regulation by 'Sirt1 [nucleoplasm]'
regulationReference	[RegulationReference:9932076] Positive gene expression regulation by 'Rora,c:Coactivators:Clock gene [nucleoplasm]' RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo [RegulationReference:9932071] Negative regulation by 'Nr1d1:heme:Corepressors:Clock gene [nucleoplasm]' Direct regulation of CLOCK expression by REV-ERB [RegulationReference:9931526] Positive gene expression regulation by 'Sirt1 [nucleoplasm]' SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:9932100] R-MMU-9932080.1
summation	[Summation:9932075] The Clock gene is transcribed in a circadian pattern to yiel...
(inferredFrom)	[BlackBoxEvent:9932070] RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK [Homo sapiens]
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No pathways have been reviewed or authored by Rora,c and coactivators positively regulate expression of Clock (9932080)