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Query author contributions in Reactome

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Details on Person The Clock gene is transcribed in a circadian pattern to yiel...

Class:IdSummation:9932075
_displayNameThe Clock gene is transcribed in a circadian pattern to yiel...
_timestamp2024-12-17 02:54:46
created[InstanceEdit:9932069] May, Bruce, 2024-12-17
textThe Clock gene is transcribed in a circadian pattern to yield mRNA and the mRNA is translated to yield Clock protein (Steeves et al. 1999, Ueda et al. 2005, Liu et al. 2007). The promoter of the Clock gene contains a ROR response element (RRE, RORE) that can bind either Rora or Rorc, both of which enhance transcription of Clock (Takeda et al. 2012). Transcription of Clock is repressed by Rev-erba, which binds a site in the first intron of the gene (Crumbley and Burris 2011).
(summation)[BlackBoxEvent:9932080] Rora,c and coactivators positively regulate expression of Clock [Mus musculus]
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