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Details on Person RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK

Class:Id	BlackBoxEvent:9932070
_displayName	RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK
_doRelease	TRUE
_timestamp	2025-02-18 21:11:02
authored	[InstanceEdit:9932069] May, Bruce, 2024-12-17
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9932069] May, Bruce, 2024-12-17
edited	[InstanceEdit:9932069] May, Bruce, 2024-12-17
inferredFrom	[BlackBoxEvent:9932080] Rora,c and coactivators positively regulate expression of Clock [Mus musculus]
input	[EntityWithAccessionedSequence:5640211] CLOCK gene [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
literatureReference	[LiteratureReference:1368902] Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei
modified	[InstanceEdit:9933409] May, Bruce, 2024-12-29 [InstanceEdit:9934287] May, Bruce, 2025-01-07 [InstanceEdit:9934784] May, Bruce, 2025-01-10 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938391] May, Bruce, 2025-02-14 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK
output	[EntityWithAccessionedSequence:400392] CLOCK [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9932081] RORA,C and coactivators bind the CLOCK gene [Homo sapiens] [BlackBoxEvent:9922984] Phosphorylated BMAL1:CLOCK positively regulates expression of RORA [Homo sapiens] [BlackBoxEvent:9925861] Phosphorylated BMAL1:CLOCK and coactivators positively regulate expression of RORC [Homo sapiens] [BlackBoxEvent:1368140] Expression of PPARGC1A (PGC-1alpha) [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeGeneExpressionRegulation:1368175] Negative gene expression regulation by 'NR1D1:heme:Corepressors:CLOCK gene [nucleoplasm]' [PositiveGeneExpressionRegulation:5656490] Positive gene expression regulation by 'SIRT1 [nucleoplasm]' [PositiveGeneExpressionRegulation:5656508] Positive gene expression regulation by 'RAI1 [nucleoplasm]' [PositiveGeneExpressionRegulation:9932083] Positive gene expression regulation by 'RORA,C:Coactivators:CLOCK gene [nucleoplasm]'
regulationReference	[RegulationReference:9642512] Positive gene expression regulation by 'RAI1 [nucleoplasm]' Smith-Magenis syndrome results in disruption of CLOCK gene transcription and reveals an integral role for RAI1 in the maintenance of circadian rhythmicity
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9932101] R-HSA-9932070.1
summation	[Summation:9932085] The CLOCK gene is transcribed (Steeves et al. 1999) in a cir... [Summation:5656485] Inferred from mouse homologs, RAI1 increases transcription o...
(hasEvent)	[Pathway:9931509] Expression of BMAL (ARNTL), CLOCK, and NPAS2 [Homo sapiens]
(precedingEvent)	[Reaction:9912396] CDK5 phosphorylates CLOCK on serine-451 and serine-461 [Homo sapiens]
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No pathways have been reviewed or authored by RORA,C and coactivators positively regulate and NR1D1 (REV-ERBA) negatively regulates expression of CLOCK (9932070)