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Details on Person AKR1B1 reduces galactose to galactitol

Class:Id	Reaction:9931850
_displayName	AKR1B1 reduces galactose to galactitol
_doRelease	TRUE
_timestamp	2025-02-25 18:07:04
authored	[InstanceEdit:9931930] Rothfels, Karen, 2024-12-13
catalystActivity	[CatalystActivity:196106] aldose reductase (NADPH) activity of AKR1B1 [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9931849] Rothfels, Karen, 2024-12-13
crossReference	[DatabaseIdentifier:9936196] RHEA:37969 [DatabaseIdentifier:9936198] RHEA:12791
edited	[InstanceEdit:9931930] Rothfels, Karen, 2024-12-13
inferredFrom	[Reaction:9931940] Akr1b1 reduces galactose to galactitol [Mus musculus]
input	[SimpleEntity:9931851] alpha-D-Gal [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29364] NADPH [cytosol]
internalReviewed	[InstanceEdit:9936141] D'Eustachio, Peter, 2025-01-20
literatureReference	[LiteratureReference:9931831] Presence of a closely related subgroup in the aldo-ketoreductase family of the mouse [LiteratureReference:9931804] Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease [LiteratureReference:9931837] The accumulation of dulcitol and water in rabbit lens incubated with galactose [LiteratureReference:9931830] Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor [LiteratureReference:9931817] Polyol accumulation in cultured human lens epithelial cells [LiteratureReference:9931841] The in vitro effects of galactose and its derivatives on rat brain Mg2+-ATPase activity [LiteratureReference:9931810] INHIBITION OF ACTION OF LENS MUTAROTASE ON GLUCOSE BY CATARACTOGENIC SUGARS AND CORRESPONDING POLYOLS
modified	[InstanceEdit:9931945] Rothfels, Karen, 2024-12-13 [InstanceEdit:9936201] Rothfels, Karen, 2025-01-21 [InstanceEdit:9936502] Rothfels, Karen, 2025-01-23 [InstanceEdit:9936509] Rothfels, Karen, 2025-01-23 [InstanceEdit:9939342] Rothfels, Karen, 2025-02-25
name	AKR1B1 reduces galactose to galactitol alpha-D-galactose+NADPH+H+=>galactitol+NADP+
output	[SimpleEntity:9931848] galactitol [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:9931853] GALM converts beta-D-GAL to alpha-D-GAL [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9936506] D'Eustachio, Peter, 2025-01-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9931856] R-HSA-9931850.1
summation	[Summation:9931809] Based on studies in mouse, ADKR1B1 catalyzes the conversion ...
(hasEvent)	[Pathway:70370] Galactose catabolism [Homo sapiens]
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No pathways have been reviewed or authored by AKR1B1 reduces galactose to galactitol (9931850)