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Details on Person RORA,C and coactivators bind the NR1D1 (REV-ERBA) gene

Class:Id	Reaction:9931531
_displayName	RORA,C and coactivators bind the NR1D1 (REV-ERBA) gene
_doRelease	TRUE
_timestamp	2025-02-18 21:10:54
authored	[InstanceEdit:9931532] May, Bruce, 2024-12-12
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9931532] May, Bruce, 2024-12-12
edited	[InstanceEdit:9931532] May, Bruce, 2024-12-12
inferredFrom	[Reaction:9931520] Rora,c, Ep300, and Ppargc1a bind the Nr1d1 gene [Mus musculus]
input	[EntityWithAccessionedSequence:5641202] NR1D1 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:381325] EP300 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:442481] PPARGC1A [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:442481] PPARGC1A [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4086031] NRIP1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4086031] NRIP1 [nucleoplasm] [Homo sapiens] [DefinedSet:9931515] RORA,RORC [nucleoplasm] [Homo sapiens] [DefinedSet:9931515] RORA,RORC [nucleoplasm] [Homo sapiens]
internalReviewed	[InstanceEdit:9936833] Matthews, Lisa, 2025-01-27
isChimeric	FALSE
literatureReference	[LiteratureReference:1480024] Transcriptional regulation of human Rev-erbalpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha
modified	[InstanceEdit:9932107] May, Bruce, 2024-12-17 [InstanceEdit:9933409] May, Bruce, 2024-12-29 [InstanceEdit:9936865] May, Bruce, 2025-01-27 [InstanceEdit:9938453] May, Bruce, 2025-02-14 [InstanceEdit:9938697] May, Bruce, 2025-02-18
name	RORA,C and coactivators bind the NR1D1 (REV-ERBA) gene
output	[Complex:9931524] RORA,C:Coactivator:NR1D1 gene [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:1368140] Expression of PPARGC1A (PGC-1alpha) [Homo sapiens] [Reaction:111912] CaMK4 phosphorylates CREB1 [Homo sapiens] [BlackBoxEvent:9922984] Phosphorylated BMAL1:CLOCK positively regulates expression of RORA [Homo sapiens] [Reaction:9923006] p-S90-BMAL1:p-T451,T461-CLOCK binds the RORA gene [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9931545] R-HSA-9931531.1
summation	[Summation:9932089] RORA binds the NR1D1 (REV-ERBA) promoter and activates trans...
(hasEvent)	[Pathway:9933387] RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9934780] RORA,C positively regulate expression and NR1D1 negatively regulates expression of NR1D1 (REV-ERBA) [Homo sapiens]
(replacementInstances)	[_Deleted:9938740] Deletion of instance: 5663273
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No pathways have been reviewed or authored by RORA,C and coactivators bind the NR1D1 (REV-ERBA) gene (9931531)