Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P69937 gdx
| Class:Id | ReferenceGeneProduct:9931177 |
|---|---|
| _chainChangeLog | chain:1-105 for 9931177 added on Fri Feb 21 2025 |
| _displayName | UniProt:P69937 gdx |
| _timestamp | 2025-02-21 18:47:05 |
| chain | chain:1-105 |
| checksum | C4686D9EDC1B7D08 |
| comment | FUNCTION Guanidinium ion exporter. Couples guanidinium export to the proton motive force, exchanging one guanidinium ion for two protons (PubMed:29507227). Overexpression leads to resistance to a subset of toxic quaternary ammonium compounds such as cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations (PubMed:11948170).SUBUNIT Homodimer. The subunits assemble with antiparallel topology.SUBCELLULAR LOCATION Transcriptionally regulated by guanidine, via a guanidine-sensing riboswitch.SIMILARITY Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Gdx/SugE subfamily.CAUTION Was originally (PubMed:8096175) thought to suppress a groEL mutation and mimic the effect of groE overexpression. This was later shown (PubMed:11948170) to be probably due to an artifact.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| created | [InstanceEdit:9931162] Stephan, Ralf, 2024-12-11 |
| description | recommendedName: fullName evidence="7"Guanidinium exporter alternativeName: fullName evidence="9"Quaternary ammonium compound-resistance protein SugE |
| geneName | gdx sugE b4148 JW5738 |
| identifier | P69937 |
| isSequenceChanged | FALSE |
| keyword | Cell inner membrane Cell membrane Ion transport Membrane Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | gdx |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | GDX_ECOLI P30743 Q2M6F4 |
| sequenceLength | 105 |
| species | [Species:159879] Escherichia coli |
| (referenceEntity) | [EntityWithAccessionedSequence:9931169] Gdx [plasma membrane] [Escherichia coli] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P69937 gdx (9931177)
