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Details on Person UniProt:P07822 fhuD
| Class:Id | ReferenceGeneProduct:9930925 |
|---|---|
| _chainChangeLog | signal peptide:1-30 for 9930925 added on Fri Feb 21 2025;chain:31-296 for 9930925 added on Fri Feb 21 2025 |
| _displayName | UniProt:P07822 fhuD |
| _timestamp | 2025-02-21 19:47:58 |
| chain | signal peptide:1-30 chain:31-296 |
| checksum | 4687A34771397D9F |
| comment | FUNCTION Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrichrome, gallichrome, desferrioxamine, coprogen, aerobactin, shizokinen, rhodotorulic acid and the antibiotic albomycin.SUBUNIT The complex is composed of two ATP-binding proteins (FhuC), a transmembrane protein (FhuB) and a solute-binding protein (FhuD) (PubMed:34887516). FhuD interacts with FhuB (PubMed:34887516, PubMed:8522527, PubMed:9426146). Substrate-loaded FhuD binds FhuB more strongly than FhuD alone (PubMed:34887516).SUBCELLULAR LOCATION Induced 1.3-fold by hydroxyurea.PTM Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system.SIMILARITY Belongs to the bacterial solute-binding protein 8 family. |
| created | [InstanceEdit:9930926] Stephan, Ralf, 2024-12-07 |
| description | recommendedName: fullName evidence="10"Iron(3+)-hydroxamate-binding protein FhuD alternativeName: fullName evidence="10"Ferric hydroxamate uptake protein D alternativeName: fullName evidence="10"Ferrichrome-binding periplasmic protein alternativeName: fullName evidence="10"Iron(III)-hydroxamate-binding protein FhuD |
| geneName | fhuD b0152 JW0148 |
| identifier | P07822 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Direct protein sequencing Ion transport Iron Iron transport Periplasm Reference proteome Signal Transport |
| modified | [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | fhuD |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | FHUD_ECOLI P77711 |
| sequenceLength | 296 |
| species | [Species:159879] Escherichia coli |
| (referenceEntity) | [EntityWithAccessionedSequence:9930924] FhuD [periplasmic space] [Escherichia coli] |
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No pathways have been reviewed or authored by UniProt:P07822 fhuD (9930925)
