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Details on Person factor Va intermediate -> factor Va

Class:Id	Reaction:9930792
_displayName	factor Va intermediate -> factor Va
_doRelease	TRUE
_timestamp	2026-01-27 16:18:41
authored	[InstanceEdit:9930783] Shamovsky, Veronica, 2024-12-06
catalystActivity	[CatalystActivity:139890] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
catalystActivityReference	[CatalystActivityReference:9930794] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region] Activation of human factor V by factor Xa and thrombin
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9930783] Shamovsky, Veronica, 2024-12-06
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
input	[Complex:9930795] factor Va intermediate [extracellular region] [Homo sapiens]
internalReviewed	[InstanceEdit:9936123] D'Eustachio, Peter, 2025-01-20
literatureReference	[LiteratureReference:140680] The factor V activation paradox [LiteratureReference:9930789] Thrombin-mediated proteolysis of factor V resulting in gradual B-domain release and exposure of the factor Xa-binding site [LiteratureReference:9930786] Novel insights into the regulation of coagulation by factor V isoforms, tissue factor pathway inhibitorα, and protein S [LiteratureReference:9934800] Factor V has an anticoagulant cofactor activity that targets the early phase of coagulation
modified	[InstanceEdit:9933749] Shamovsky, Veronica, 2025-01-03 [InstanceEdit:9934818] Shamovsky, Veronica, 2025-01-10 [InstanceEdit:9938615] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938673] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938848] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9979552] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980355] Shamovsky, Veronica, 2026-01-27
name	factor Va intermediate -> factor Va FVa intermediate -> FVa
output	[Complex:140692] factor Va [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9933750] factor V (1047-1573) [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:9769737] factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst) [Homo sapiens] [Reaction:9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa [Homo sapiens] [Reaction:9930790] factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst) [Homo sapiens] [Reaction:9822512] TF:FVIIa:FXa ->TF:FVIIa + FXa [Homo sapiens] [Reaction:9929060] TF:FVII:FXa ->TF:FVIIa:FXa (FXa catalyst) [Homo sapiens] [Reaction:9822514] TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst) [Homo sapiens]
regulatedBy	[NegativeRegulation:9938617] Negative regulation by 'TFPIα:FV intermediate:PROS1 [extracellular region]'
regulationReference	[RegulationReference:9938616] Negative regulation by 'TFPIα:FV intermediate:PROS1 [extracellular region]' Tissue factor pathway inhibitor-alpha inhibits prothrombinase during the initiation of blood coagulation
releaseDate	2026-03-25
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9930803] R-HSA-9930792.1
structureModified	[InstanceEdit:9933749] Shamovsky, Veronica, 2025-01-03 [InstanceEdit:9938615] Shamovsky, Veronica, 2025-02-18
summation	[Summation:9930796] Coagulation factor V (FV, encoded by the F5 gene) circulates...
(hasEvent)	[Pathway:9769735] Initiation of coagulation cascade [Homo sapiens]
(precedingEvent)	[Reaction:140686] factor Va + factor Xa -> Va:Xa complex (prothrombinase) [Homo sapiens]
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No pathways have been reviewed or authored by factor Va intermediate -> factor Va (9930792)