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Details on Person factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst)

Class:Id	Reaction:9930790
_displayName	factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst)
_doRelease	TRUE
_timestamp	2026-01-27 16:18:34
authored	[InstanceEdit:9930783] Shamovsky, Veronica, 2024-12-06
catalystActivity	[CatalystActivity:139890] serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9930783] Shamovsky, Veronica, 2024-12-06
edited	[InstanceEdit:9937613] Shamovsky, Veronica, 2025-02-05
input	[EntityWithAccessionedSequence:140697] factor V [extracellular region] [Homo sapiens]
internalReviewed	[InstanceEdit:9936123] D'Eustachio, Peter, 2025-01-20
literatureReference	[LiteratureReference:9930552] Activation of human factor V by factor Xa and thrombin [LiteratureReference:140680] The factor V activation paradox [LiteratureReference:9930789] Thrombin-mediated proteolysis of factor V resulting in gradual B-domain release and exposure of the factor Xa-binding site [LiteratureReference:9930786] Novel insights into the regulation of coagulation by factor V isoforms, tissue factor pathway inhibitorα, and protein S
modified	[InstanceEdit:9938612] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938671] Shamovsky, Veronica, 2025-02-18 [InstanceEdit:9938847] Shamovsky, Veronica, 2025-02-20 [InstanceEdit:9979547] Shamovsky, Veronica, 2026-01-20 [InstanceEdit:9980355] Shamovsky, Veronica, 2026-01-27
name	factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst)
output	[Complex:9930795] factor Va intermediate [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:9930787] factor V (738-1046) [extracellular region] [Homo sapiens]
releaseDate	2026-03-25
reviewStatus	[ReviewStatus:9821383] three stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9930798] R-HSA-9930790.1
summation	[Summation:9930791] Coagulation factor V (FV, encoded by the F5 gene) is activat...
(hasEvent)	[Pathway:9769735] Initiation of coagulation cascade [Homo sapiens]
(precedingEvent)	[Reaction:9930792] factor Va intermediate -> factor Va [Homo sapiens] [Reaction:9931628] TFPIα + FV intermediate + PROS1 => TFPIα:FV intermediate:PROS1 [Homo sapiens] [Reaction:9933742] factor Va intermediate + factor Xa -> factor Va intermediate:factor Xa [Homo sapiens]
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No pathways have been reviewed or authored by factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst) (9930790)